| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Shahbazi, Mohammad-Ali
University Medical Center Groningen
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (18/18 displayed)
- 2024Designing of a Multifunctional 3D-Printed Biomimetic Theragenerative Aerogel Scaffold via Mussel-Inspired Chemistrycitations
- 2023Dermal Wound Healingcitations
- 2023Nanoparticles-based phototherapy systems for cancer treatmentcitations
- 2023Nanoparticles-based phototherapy systems for cancer treatment:Current status and clinical potentialcitations
- 2023Effect of poly (lactic-co-glycolic acid) polymer nanoparticles loaded with vancomycin against Staphylococcus aureus biofilmcitations
- 2023Injectable Nanocomposite Hydrogels of Gelatin-Hyaluronic Acid Reinforced with Hybrid Lysozyme Nanofibrils-Gold Nanoparticles for the Regeneration of Damaged Myocardiumcitations
- 2021Electroconductive multi-functional polypyrrole composites for biomedical applicationscitations
- 2020Directional Freeze-Castingcitations
- 2020Controlled Tyrosine Kinase Inhibitor Delivery to Liver Cancer Cells by Gate-Capped Mesoporous Silica Nanoparticlescitations
- 2019Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approachcitations
- 2019Silica nanoparticle surface chemistry: An important trait affecting cellular biocompatibility in two and three dimensional culture systemscitations
- 2018Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regenerationcitations
- 2018Conductive vancomycin-loaded mesoporous silica polypyrrole-based scaffolds for bone regenerationcitations
- 2017A Multifunctional Nanocomplex for Enhanced Cell Uptake, Endosomal Escape and Improved Cancer Therapeutic Effectcitations
- 2017Intracellular responsive dual delivery by endosomolytic polyplexes carrying DNA anchored porous silicon nanoparticlescitations
- 2016Oral hypoglycaemic effect of GLP-1 and DPP4 inhibitor based nanocomposites in a diabetic animal modelcitations
- 2015Cyclodextrin-Modified Porous Silicon Nanoparticles for Efficient Sustained Drug Delivery and Proliferation Inhibition of Breast Cancer Cellscitations
- 2015Microfluidic Nanoprecipitation of a Stimuli Responsive Hybrid Nanocomposite for Antitumoral Applications
Places of action
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article
A Multifunctional Nanocomplex for Enhanced Cell Uptake, Endosomal Escape and Improved Cancer Therapeutic Effect
Abstract
Aim: To evaluate the chemotherapeutic potential of a novel multifunctional nanocomposite encapsulating both porous silicon (PSi) and gold (Au) nanoparticles in a polymeric nanocomplex. Materials & Methods: The nanocomposite was physicochemically characterized and evaluated in vitro for biocompatibility, cellular internalization, endosomolytic properties, cytoplasmatic drug delivery and chemotherapeutic efficacy. Results: The nanocomposites were successfully produced and exhibited adequate physicochemical properties and superior in vitro cyto- and hemo-compatibilities. The encapsulation of PSi nanoparticles in the nanocomplexes significantly enhanced their cellular internalization and enabled their endosomal escape, resulting in the efficient cytoplasmic delivery of these nanosystems. Sorafenib-loaded nanocomposites showed a potent in vitro anti-proliferative effect on MDA-MB-231 breast cancer cells. Conclusion: The multifunctional nanocomposite herein presented exhibits great potential as a chemotherapeutic nanoplatform.