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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kumar, Arun
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2024Lanthanum(III)hydroxide Nanoparticles and Polyethyleneimine-Functionalized Graphene Quantum Dot Nanocomposites in Photosensitive Silicon Heterojunctionscitations
- 2024Fabrication of Highly Efficient and Ambient Stable Planar MAPbI<sub>3</sub> Perovskite Solar Cells via Defect Passivation through Crosslinking Strategycitations
- 2022Interface Analysis of MOCVD Grown GeTe/Sb2Te3 and Ge-Rich Ge-Sb-Te/Sb2Te3 Core-Shell Nanowirescitations
- 2022Highly Sensitive Refractive Index Sensor based on Polymer Bragg Grating: A case study on Extracellular Vesicles Detectioncitations
- 2021Large-Area {MOVPE} Growth of Topological Insulator Bi2Te3 Epitaxial Layers on i-Si(111)citations
- 2021Spin-Charge Conversion in Fe/Au/Sb2Te3 Heterostructures as Probed By Spin Pumping Ferromagnetic Resonancecitations
- 2021Magnetic ground state and crystal structure of the giant dielectric constant material $Ba(Fe_{1/2}Nb_{1/2})O_{3}$citations
- 2020Synthesis of Nanostructured Lipid Carriers Loaded Chitosan/ Carbopol Hybrid Nanocomposite Gel for Oral Delivery of Artemether and Curcumincitations
- 2019Carbon nanotubes synthesis using siliceous breccia as a catalyst sourcecitations
- 2019Evidence for cluster spin glass phase with precursor short-range antiferromagnetic correlations in the B -site disordered $CaFe(_{1/2}Nb_{1/2})O_{3}$ perovskitecitations
- 2019Superior thermomechanical and wetting properties of ultrasonic dual mode mixing assisted epoxy-CNT nanocompositescitations
- 2019Influence of nanosilica on mechanical and durability properties of concretecitations
- 2018Viscoelastic and thermally stable PDMS–SiO<sub>2</sub> filled epoxy adhesive joint on steel substratecitations
- 2018Natural Laterite as a Catalyst Source for the Growth of Carbon Nanotubes and Nanospherescitations
- 2016Anticorrosive and electromagnetic shielding response of a graphene/TiO<sub>2</sub>–epoxy nanocomposite with enhanced mechanical propertiescitations
- 2015Carbon Wrapped Sulfur Cathode Materials for Rechargeable Batteries
- 2009Structural and Electrochemical Characterization of Pure<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>LiFePO</mml:mtext><mml:mtext>4</mml:mtext></mml:msub></mml:math>and Nanocomposite C-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mtext>LiFePO</mml:mtext><mml:mtext>4</mml:mtext></mml:msub></mml:math>Cathodes for Lithium Ion Rechargeable Batteriescitations
- 2009Bragg grating based biochemical sensor using submicron Si/SiO2 waveguides for lab-on-a-chip applications: a novel designcitations
- 2009Highly sensitive biochemical sensor utilizing Bragg grating in submicron Si/SiO2 waveguides
- 2009Refractive index sensing characteristics of dual resonance long period gratings in bare and metal-coated D-shaped fiberscitations
- 2008Side-Polished Optical Fiber Grating-Based Refractive Index Sensors Utilizing the Pure Surface Plasmon Polaritoncitations
Places of action
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article
Synthesis of Nanostructured Lipid Carriers Loaded Chitosan/ Carbopol Hybrid Nanocomposite Gel for Oral Delivery of Artemether and Curcumin
Abstract
<jats:sec> <jats:title> Background:</jats:title> <jats:p>Antimalarial therapy remains the utmost effective means for the management of malarial parasites in the liver and red blood cells. The application of these therapeutic agents is hampered by their improper application, hepato-toxicity caused by their continuous use, and degradation by hepatic enzymes.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods:</jats:title> <jats:p>Recent advancements in drug delivery applications have shown potential in improving the pharmacological properties of artemether. Nanostructured lipid carriers (NLCs) loaded chitosan (CH)/Carbopol (CB) hybrid gel was prepared using glycerol monostearate (GMS) as solid lipid and clove oil as a liquid lipid for artemether (ART) and curcumin (CR) for its localized effect on the liver.</jats:p> </jats:sec> <jats:sec> <jats:title>Results:</jats:title> <jats:p>The smaller particle size (~118 ± 1.0 nm) and high zeta potential (- 41.1 ± 6.46 mV) confirm the formulation and stability of NLCs. On the other hand, the shape and morphology of prepared NLCs and gel showed a spherical and wrinkled surface with a size range of 150-250 nm. The release studies of the NLC’s showed a controlled release of artemether (~ 92%) and curcumin (~ 83%) for up to 30 h. Photostability data showed that, approximately, ~86.5 ± 0.3% and ~60 ± 0.9% of nanoencapsulated artemether and curcumin were still detected on exposure to sunlight, respectively. It has been found from the permeation study that 69.8% and 49.1% of the drug was permeated across the mucus membrane in 24 h with a significant increase (P < 0.05) in flux as well as permeability coefficients.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion:</jats:title> <jats:p>The overall results showed that prepared CH/CB/NLCs hybrid gel could be a promising vehicle for the effective delivery of ART and CR for the management of malarial parasites. Lay Summary: Antimalarial therapy remains the utmost effective means for the management of malarial parasites in liver and red blood cells. Recent advancements in drug delivery applications have shown potential in improving the pharmacological properties of artemether. Application of these therapeutic agents hampered by their improper application, hepato-toxicity caused by their continuous use and degradation by hepatic enzymes. To manage the above issues, we synthesize nanostructured lipid carriers (NLC’s) loaded chitosan (CH)/Carbopol (CB) hybrid gel using glycerol monostearate (GMS) as solid lipid and clove oil as liquid lipid for artemether (ATR) and curcumin (CR) for its local action in liver and the major criteria were to find a protective barrier with hepatoprotective nature of the curcumin.</jats:p> </jats:sec>