| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Major, Ian
Irish Research Council
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (41/41 displayed)
- 2024Material compatibility and processing challenges in droplet deposition modelling additive manufacturingcitations
- 2024Material compatibility and processing challenges in droplet deposition modelling additive manufacturing: A study on pharmaceutical excipients Polyvinylpyrrolidone/vinyl acetate (PVP/VA) and Polycaprolactone (PCL)citations
- 2023Modification of hyaluronic acid to enable click chemistry photo-crosslinking of hydrogels with tailorable degradation profilescitations
- 2023Designing Sustainable Polymer Blendscitations
- 2023Designing sustainable polymer blends: tailoring mechanical properties and degradation behaviour in PHB/PLA/PCL blends in a seawater environmentcitations
- 2023Sustainable polyurethane coatings based on functional Camelina oil-based polyolscitations
- 2023Synergy Assessment of Four Antimicrobial Bioactive Compounds for the Combinational Treatment of Bacterial Pathogenscitations
- 2021Influence of extrusion screw speed on the properties of halloysite nanotube impregnated polylactic acid nanocompositescitations
- 2021Influence of extrusion screw speed on the properties of halloysite nanotube impregnated polylactic acid nanocompositescitations
- 2021On the possibility of replacement of calcium carbonate by a high-performance, economically viable filler in polyethylene composites
- 2021Development of a low-temperature extrusion process for production of GRAS bioactive-polymer loaded compounds for targeting antimicrobial-resistant (AMR) bacteriacitations
- 2020Effect of stereolithography 3d printing on the properties of pegdma hydrogelscitations
- 2020Fused filament fabrication of peekcitations
- 2020Effect of stereolithography 3D printing on the properties of PEGDMA hydrogels.citations
- 2019Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tabletscitations
- 2019Influence of annealing and biaxial expansion on the properties of Poly-l-lactic) medical tubing.citations
- 2019Additive manufacturing of PLA/HNT nanocomposites for biomedical applicationscitations
- 2019Influence of Annealing and Biaxial Expansion on the Properties of Poly(l-Lactic Acid) Medical Tubingcitations
- 2019Influence of annealing and biaxial expansion on the properties of poly(l-lactic acid) medical tubingcitations
- 2019Faster release of lumen-loaded drugs than matrix-loaded equivalent in polylactic acid/halloysite nanotubescitations
- 2018Material considerations for fused-filament fabrication of solid dosage forms.citations
- 2018Material considerations for fused-filament fabrication of solid dosage formscitations
- 2016Synthesis and characterization of high density polyethylene/peat ash compositescitations
- 2016Chemical surface modification of calcium carbonate particles with stearic acid using different treating methodscitations
- 2016Characteristics of the treated calcium carbonate particles with stearic acid using different treating methods. ; Chemical surface modification of calcium carbonate particles with stearic acid using different treating methods
- 2015Thermal Degradation of Bio-nanocompositescitations
- 2015Hot melt extruded and injection moulded dosage formscitations
- 2013A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirinecitations
- 2012Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal rings.citations
- 2012Development of polylactide and polyethylene vinyl acetate blends for the manufacture of vaginal ringscitations
- 2006Structure and performance of ABS-clay nanocomposites by melt compounding
- 2006Structure-property and pigment/organoclay interaction in PP nanocomposites
- 2006Structure and performance of novel acrylonitrile-styrene-acrylate nanocomposite
- 2005Polymorphism and crystallisation in metallocene PP-copolymer nanocomposites
- 2005Optimise organoclay exfoliation in polymer nanocomposites by customising the extrusion temperature gradient
- 2005Structure-property of pigmented polypropylene nanocomposites incorporating organo-layered silicates
- 2004Effect of phthalocyanine blue pigment on mechanical and thermal properties of polypropylene copolymerscitations
- 2004Comparison of the effect of pigments on the mechanical and thermal properties on two different catalysed propylene-ethylene random copolymers
- 2003The mechanical properties and crystallization behaviour of pigmented propylene-ethylene random copolymer
- 2003The effect of phthalocyanine pigment on the microstructural and mechanical performance of propylene-ethylene block copolymer
- 2003The structure am performance of injection moulded, pigmented polypropylene copolymers
Places of action
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article
Hot melt extruded and injection moulded dosage forms
Abstract
<p>Hot Melt Extrusion (HME) and Injection Moulding (IM) are becoming more prevalent in the drug delivery field due to their continuous nature and advantages over current pharmaceutical manufacturing techniques. Hot melt extrusion (HME) is a process that involves the use of at least one reciprocating screw to force a thermoplastic resin along a heated barrel and through a die, while injection moulding is a forming process were molten polymer is forced at high pressure to enter a mould. HME offers a number of advantages over conventional pharmaceutical manufacturing techniques such as increased solubility and bioavailability of poorly water soluble drugs, a solvent free and continuous process, improved content uniformity and flexibility in manufacture. Injection moulding (IM) has been recognised as a rapid and versatile manufacturing technique, which has the advantages of being a continuous process, which is easily scaled up by the use of larger equipment and moulds. However, despite their advantages and the significant number of publications and patents on HME and IM drug delivery devices there are very few marketed formulations. These marketed products range from oral dosage forms which improve bioavailability and reduce pill burden to vaginal rings which provide long-term controlled release thus improving patient compliance. The patenting strategy for IM and HME seems to be focused towards patenting the finished product, more so than patenting the manufacturing process. This is probably due to the fact that the IM and HME processes have already been patented. Conclusion: HME is a process where raw materials (i.e. polymer, plasticizer, drug etc.) are mixed and pumped along by a rotating screw(s) at elevated temperatures through a die to produce a product of uniform shape. IM is similar to HME except that the raw materials are pushed into a mould which is set at lower temperatures. Interest in the use of HME and IM within the pharmaceutical industry is growing with as steady increase in the number of HME patents being issued and with more than 10 products, ranging from oral dosage forms to implantable devices, currently on the market. Therefore, this review of HME and IM is important to the scientific community to further understand and advance these novel and exciting manufacturing techniques.</p>