| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rodrigues, João
Universidade da Madeira
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (25/25 displayed)
- 2024Epidemiological and clinical trends of visceral leishmaniasis in Portugal: retrospective analysis of cases diagnosed in public hospitals between 2010 and 2020citations
- 2023Biological Effects in Cancer Cells of Mono- and Bidentate Conjugation of Cisplatin on PAMAM Dendrimers: A Comparative Studycitations
- 2023Experimental characterization of the nonlinear thermomechanical behaviour of refractory masonry with dry jointscitations
- 2023Target-Specific Delivery and Bioavailability of Pharmaceuticals via Janus and Dendrimer Particlescitations
- 2023Carbon dots and dendrimers nanohybrids: from synthesis to applicationscitations
- 2022Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocompositescitations
- 2022New insights into ruthenium(ii) metallodendrimers as anticancer drug nanocarriers: from synthesis to preclinic behaviourcitations
- 2022Dendrimers and dendrimersomes as a novel tool for effective drug delivery applicationscitations
- 2022Strain-modulated optical response in 2D MoSe2 made by Na-assisted CVD on glasscitations
- 2021Use of Half-Generation PAMAM Dendrimers (G0.5-G3.5) with Carboxylate End-Groups to Improve the DACHPtCl(2) and 5-FU Efficacy as Anticancer Drugscitations
- 2021Efficient reSe2 photodetectors with CVD single-crystal graphene contactscitations
- 2021Cytocompatible cellulose nanofibers from invasive plant species Agave americana L. and Ricinus communis L.: a renewable green source of highly crystalline nanocellulosecitations
- 2020A Review on Thermoplastic or Thermosetting Polymeric Matrices Used in Polymeric Composites Manufactured with Banana Fibers from the Pseudostemcitations
- 2019Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2)citations
- 2018Mechanical Properties of Alumina Nanofilled Polymeric Composites Cured with DDSA and MNAcitations
- 2018Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Cancer Cells and Human Mesenchymal Stem Cellscitations
- 2018Recent therapeutic applications of the theranostic principle with dendrimers in oncologycitations
- 2017The influence of curing agents in the impact properties of epoxy resin nanocompositescitations
- 2016Effect of irregular shaped nanoalumina on the enhancement of mechanical properties of epoxy resin nanocomposites using DDM as hardenercitations
- 2015Octadecyl functionalized core-shell magnetic silica nanoparticle as a powerful nanocomposite sorbent to extract urinary volatile organic metabolitescitations
- 2015PAMAM Dendrimer/pDNA Functionalized-Magnetic Iron Oxide Nanoparticles for Gene Deliverycitations
- 2012The Effect of PAMAM Dendrimers on Mesenchymal Stem Cell Viability and Differentiationcitations
- 2012Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applicationscitations
- 2011ChemInform Abstract: Poly(alkylidenamines) Dendrimers as Scaffolds for the Preparation of Low‐Generation Ruthenium Based Metallodendrimers
- 2008Visible-light photolytic synthesis of multinuclear and dendritic iron-nitrile cationic complexes
Places of action
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document
The Effect of PAMAM Dendrimers on Mesenchymal Stem Cell Viability and Differentiation
Abstract
Stem cells and nanomaterials are two new and exciting fields of science that are evolving very fast and that are starting to establish ties. Nanomaterials should, however, be designed to interact with stem cells without compromising their biological characteristics, in other words, without affecting their viability and differentiation potential. In the present report and for the first time, the effects of poly(amidoamine) (PAMAM) dendrimers on the viability and differentiation ability towards the osteogenic and adipogenic lineages of human mesenchymal stem cells (hMSCs) are systematically evaluated. Studies were done as a function of the cell culture media composition and PAMAM dendrimer surface functionalization, generation, and concentration. hMSCs were exposed to amino and hydroxyl (generations 2, 4 and 6), and carboxylate (generations 1.5, 3.5 and 5.5) functionalized dendrimers, at two different concentrations (10 mu g/mL and 0.5 mu g/mL), for a period of 21 days. Overall, the results revealed that amino functionalized dendrimers can be severely cytotoxic, the extension of cell death being dependent on the concentration of amino groups in solution. However, in all cases, the differentiation of hMSCs towards the osteogenic and adipogenic phenotypes seems not to be affected as demonstrated by staining in in vitro cultures.