| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Karagiannidis, Panagiotis
University of Sunderland
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (22/22 displayed)
- 2024Magnetic-Responsive Triple Shape Memory Polymer from Bio-Based Benzoxazine/Urethane Polymer Alloys with Iron Oxide Nanoparticlescitations
- 2024Biocompatibility, thermal and mechanical properties of glass fiber‐reinforced polybenzoxazine composites as a potential new endodontic postcitations
- 2023New nanocomposites based on poly(benzoxazine-co-epoxy) matrix reinforced by novel graphene single and mixed blend fillerscitations
- 2023Mechanical properties and curing kinetics of bio-based benzoxazine–epoxy copolymer for dental fiber postcitations
- 2023Thermal Interface Materials with Hexagonal Boron Nitride and Graphene Fillers in PDMS Matrix: Thermal and Mechanical Propertiescitations
- 2022Development of a new birthing model material based on silicone rubber/ natural rubber blendcitations
- 2022Βio-Based Epoxy/Amine Reinforced with Reduced Graphene Oxide (rGO) or GLYMO-rGO: Study of Curing Kinetics, Mechanical Properties, Lamination and Bonding Performancecitations
- 2022Bio-Based Epoxy/Amine Reinforced with Reduced Graphene Oxide (rGO) or GLYMO-rGO: Study of Curing Kinetics, Mechanical Properties, Lamination and Bonding Performancecitations
- 2020Development of new graphene/epoxy nanocomposites and study of cure kinetics, thermal and mechanical propertiescitations
- 2020Effect of sintering techniques on microstructural, mechanical and tribological properties of Al-SiC compositescitations
- 2020Highly filled graphite/graphene/carbon nanotube in polybenzoxazine composites for bipolar plate in PEMFCcitations
- 2020Effects of chemical structure and morphology of graphene-related materials (GRMs) on melt processing and properties of GRM/polyamide-6 nanocompositescitations
- 2020Development of Lightweight and High-Performance Ballistic Helmet Based on Poly(Benzoxazine-co-Urethane) Matrix Reinforced with Aramid Fabric and Multi-Walled Carbon Nanotubescitations
- 20193-Phase Hierarchical Graphene-based Epoxy Nanocomposite Laminates for Automotive Applicationscitations
- 2019Development of graphene-based materials from printing inks and coatings to structural composites
- 2017Production of graphene by solution processing and development of graphene-based materials
- 2014Performance of hybrid buffer Poly(3,4-ethylenedioxythiophene) poly(styrenesulfonate) layers doped with plasmonic silver nanoparticlescitations
- 2014High performance transistors based on the controlled growth of triisopropylsilylethynyl-pentacene crystals via non-isotropic solvent evaporationcitations
- 2013Bioelectronics meets nanomedicine for cardiovascular implants: PEDOT-based nanocoatings for tissue regenerationcitations
- 2012Novel nanostructured biomaterials: implications for coronary stent thrombosis.citations
- 2012Development of a nanoporous and multilayer drug-delivery platform for medical implantscitations
- 2009Physical Properties of a Hybrid and a Nanohybrid Dental Light-Cured Resin Compositecitations
Places of action
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article
Development of a nanoporous and multilayer drug-delivery platform for medical implants
Abstract
Biodegradable polymers can be applied to a variety of implants for controlled and local drug delivery. The aim of this study is to develop a biodegradable and nanoporous polymeric platform for a wide spectrum of drug-eluting implants with special focus on stent-coating applications. It was synthesized by poly(DL-lactide-co-glycolide) (PLGA 65:35, PLGA 75:25) and polycaprolactone (PCL) in a multilayer configuration by means of a spin-coating technique. The antiplatelet drug dipyridamole was loaded into the surface nanopores of the platform. Surface characterization was made by atomic force microscopy (AFM) and spectroscopic ellipsometry (SE). Platelet adhesion and drug-release kinetic studies were then carried out. The study revealed that the multilayer films are highly nanoporous, whereas the single layers of PLGA are atomically smooth and spherulites are formed in PCL. Their nanoporosity (pore diameter, depth, density, surface roughness) can be tailored by tuning the growth parameters (eg, spinning speed, polymer concentration), essential for drug-delivery performance. The origin of pore formation may be attributed to the phase separation of polymer blends via the spinodal decomposition mechanism. SE studies revealed the structural characteristics, film thickness, and optical properties even of the single layers in the triple-layer construct, providing substantial information for drug loading and complement AFM findings. Platelet adhesion studies showed that the dipyridamole-loaded coatings inhibit platelet aggregation that is a prerequisite for clotting. Finally, the films exhibited sustained release profiles of dipyridamole over 70 days. These results indicate that the current multilayer phase therapeutic approach constitutes an effective drug-delivery platform for drug-eluting implants and especially for cardiovascular stent applications.