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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Yan, M.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2020Tensile toughening of powder-injection-molded β Ti-Nb-Zr biomaterials by adjusting TiC particle distribution from aligned to dispersed patterncitations
- 2018Enhancement of surface bioactivity on carbon fiber-reinforced polyether ether ketone via graphene modification.citations
- 2010Microstructural and chemical aspects of working-temperature aged Ca-doped CeO2citations
- 2007Characterization of frequency noise on a broadband infrared frequency comb using optical heterodyne techniques
- 2003Dielectric response of lanthanum-modified Pb(Fe1/2Ta 1/2)O3 relaxor ferroelectricscitations
- 2002Dielectric behavior of Mn-doped morphotropic phase boundary composition in the Pb(Zn1/3Nb2/3)O3-BaTiO3- PbTiO3 system
- 2002Dielectric behavior of Mn-doped morphotropic phase boundary composition in the Pb(Zn1/3Nb2/3)O-3-BaTiO3-PbTiO3 system
- 2002Effect of lanthanum-doping on the dielectric properties of Pb(Fe1/2Ta1/2)O-3 relaxor ferroelectrics
- 2002Effect of lanthanum-doping on the dielectric properties of Pb(Fe1/2Ta1/2)O3 relaxor ferroelectrics
- 2002Phase diagram of the W-doped Pb(Zn1/3Nb2/3)O-3-BaTiO3- PbTiO3 system around a morphotropic phase boundary composition
- 2002Effect of tungsten doping on the dielectric response of PZN-PT-BT ceramics with the morphotropic phase boundary compositioncitations
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article
Enhancement of surface bioactivity on carbon fiber-reinforced polyether ether ketone via graphene modification.
Abstract
<h4>Background and objective</h4>The modulus of carbon fiber-reinforced polyether ether ketone (CFR-PEEK), a composite containing layers of carbon fiber sheets, can be precisely controlled to match bone. However, CFR-PEEK is biologically inert and cannot promote bone apposition. The objective of this study was to investigate whether graphene modification could enhance the bioactivity of CFR-PEEK.<h4>Methods and results</h4>In vitro, the proliferation and differentiation of rat bone marrow stromal cells on scaffolds were quantified via cell-counting kit-8 assay and Western blotting analysis of osteoblast-specific proteins. Graphene modification significantly promoted bone marrow stromal cell proliferation and accelerated induced differentiation into osteogenic lineages compared to cells seeded onto nongraphene-coated CFR-PEEK. An in vivo rabbit extraarticular graft-to-bone healing model was established. At 4, 8, and 12 weeks after surgery, microcomputed tomography analyses and histological observations revealed significantly better microstructural parameters and higher average mineral apposition rates for graphene-modified CFR-PEEK implants than CFR-PEEK implants (<i>P</i><0.05). van Gieson staining indicated more new bone was formed around graphene-modified CFR-PEEK implants than CFR-PEEK implants.<h4>Conclusion</h4>Graphene may have considerable potential to enhance the bioactivity and osseointegration of CFR-PEEK implants for clinical applications.