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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ready, Derren
Public Health England
in Cooperation with on an Cooperation-Score of 37%
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Publications (5/5 displayed)
- 2021Determining the acceptability of testing contacts of confirmed COVID-19 cases to improve secondary case ascertainmentcitations
- 2021Engagement with daily testing instead of self-isolating in contacts of confirmed cases of SARS-CoV-2citations
- 2014Sequential identification of a degradable phosphate glass scaffold for skeletal muscle regeneration
- 2010Association Between Interleukin-6-174 Polymorphism and Aggregatibacter actinomycetemcomitans in Chronic Periodontitis
- 2008Interleukin-6 polymorphisms are associated with pathogenic bacteria in subjects with periodontitiscitations
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article
Interleukin-6 polymorphisms are associated with pathogenic bacteria in subjects with periodontitis
Abstract
Background: Growing evidence suggests that individual genetic susceptibility may influence the host's response to infections. Previously, we showed that a common variation in the interleukin (IL)-6 gene was associated with increased odds of detection of common periodontal pathogens from individuals with aggressive periodontitis. The aim of this study was to investigate the association between IL-6 polymorphisms and periodontopathogenic bacteria in a larger, ethnically mixed population of subjects with periodontitis.Methods: Genomic DNA was extracted from 107 subjects diagnosed with severe forms of periodontitis to study a cluster of polymorphisms in inflammatory genes, including IL-6. The presence of Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), Porphyromonas gingivalis, and Tannerella forsythia (previously T forsythensis) in their subgingival biofilm was determined by polymerase chain reaction analysis. Serum IL-6 and C-reactive protein (CRP) concentrations were analyzed by enzyme-linked immunosorbent assay.Results: Multiple logistic regression analysis revealed that the IL-6 -6106 polymorphism was associated with the detection of A. actinomycetemcomitans (P= 0.009; odds ratio [OR] = 3.5; 95% confidence interval [Cl]: 1.38 to 9.16) and the concomitant detection of A. actinomycetemcomitans and P. gingivalis (P = 0.015; OR = 3.6; 95% Cl: 1.28 to 10.04). The IL-6-174 polymorphism was associated with increased odds of the concomitant detection of A. actinomycetemcomitans and P. gingivalis (P= 0.042; OR = 2.8; 95% Cl: 1.04 to 7.75). Haplotype analysis of all five IL-6 polymorphisms confirmed an association with the detection of A. actinomycetemcomitans (P= 0.046). The IL-6 -6106 polymorphism was also associated with CRP serum levels at multivariate analysis (P= 0.024).Conclusions: These findings confirm the hypothesis that complex interactions between the microbiota and host genome are at the basis of susceptibility to periodontitis. Periodontal disease may represent a useful model to study the pathways and mechanisms of host-pathogen interactions in inflammatory diseases.