| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Seitz, Hermann
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (20/20 displayed)
- 2024Quantitative Macromolecular Modeling Assay of Biopolymer-Based Hydrogelscitations
- 2024Direct ink writing of highly loaded polycaprolactone-barium titanate/bioactive glass composites for osteochondral tissue engineering
- 2023Piezoelectric and bioactive composites: Functional materials for bone tissue engineering
- 20223D printed gelatin/decellularized bone composite scaffolds for bone tissue engineering: Fabrication, characterization and cytocompatibility studycitations
- 2022A novel approach to fabricate load-bearing Ti6Al4V-Barium titanate piezoelectric bone scaffolds by coupling electron beam melting and field-assisted sintering
- 2022The influence of PEGDA’s molecular weight on its mechanical properties in the context of biomedical applicationscitations
- 2021Rapid tooling for micro injection molding of micro medical devices via digital light processing
- 20213D printing of biodegradable poly(L-lactide)/hydroxyapatite composite by composite extrusion modeling
- 2021Heat accumulation during femtosecond laser treatment at high repetition rate – A morphological, chemical and crystallographic characterization of self-organized structures on Ti6Al4V
- 2021Tunable Pseudo-Piezoelectric Effect in Doped Calcium Titanate for Bone Tissue Engineering
- 20203D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineeringcitations
- 2020Sintering behavior of 3D printed barium titanate composite scaffolds for bone repair
- 2020PEGDA drug delivery scaffolds manufactured with a novel hybrid AM process
- 20203D printing of frames for anti-coronavirus face shields using different processes and materials
- 20193D-printed PEGDA structure with multiple depots for advanced drug delivery systems
- 2019A Novel Hybrid Additive Manufacturing Process for Drug Delivery Systems with Locally Incorporated Drug Depots. citations
- 2019Thermomechanical properties of PEGDA in combination with different photo-curable comonomerscitations
- 20193D printing of smart materials for bone regeneration
- 2018Thermomechanical properties of PEGDA and its co-polymerscitations
- 2007Non-toxic flexible photopolymers for medical stereolithography technologycitations
Places of action
| Organizations | Location | People |
|---|
document
Piezoelectric and bioactive composites: Functional materials for bone tissue engineering
Abstract
When deformed, piezoelectric biomaterials generate electricity, creating a microenvironment to electrically stimulate cells, which can restore essential functions in biological tissues. In previous studies, the beneficial effects of electrical stimulation have shown to significantly impacted bone formation, cartilage repair, and neurological tissue regeneration [1]–[4]. However, preparing piezoelectric and bioactive bone substitute materials remains a challenge in the field. Here, we report barium titanate composites in combination with established bone substitute materials, such as hydroxyapatite, or bioactive glass, as multi-functional bone substitute materials. By 3D printing, the piezoelectric composites are processed into porous and piezoelectric scaffolds, achieving piezoelectric constants d33 of 3-40 pC/N, which are in the range of native bone or above [5]. Especially with 45S5 bioactive glass, the materials show profound cytocompatibility and bioactive properties, inducing the formation of calcium phosphates on the scaffold surface. Piezoelectric composites based on barium titanate combined with modern manufacturing methods represent a promising approach to create bioactive and electrically stimulating implants. In the future, the electricity and bioactivity generated by such materials at the implant site may be harnessed without an external source or electrodes, thus acting as autonomous electroactive implants. Author’s statement Conflict of interest: Authors state no conflict of interest. Informed consent: Informed consent has been obtained from all individuals included in this study. Acknowledgments: This research was funded by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – SFB 1270/1,2 – 299150580. References [1] R. Balint, N. J. Cassidy, and S. H. Cartmell, “Electrical Stimulation: A Novel Tool for Tissue Engineering,” Tissue Eng. Part B Rev., vol. 19, no. 1, pp. 48–57, 2013. [2] B. Tandon, J. J. Blaker, and S. H. Cartmell, “Piezoelectric materials as stimulatory biomedical materials and scaffolds for bone repair,” Acta Biomater., vol. 73, pp. 1–20, Jun. 2018. [3] L. Leppik, K. M. C. Oliveira, M. B. Bhavsar, and J. H. Barker, “Electrical stimulation in bone tissue engineering treatments,” European Journal of Trauma and Emergency Surgery, vol. 46, no. 2. Springer, pp. 231–244, 01-Apr-2020. [4] C. Polley et al., “3D Printing of Piezoelectric Barium Titanate-Hydroxyapatite Scaffolds with Interconnected Porosity for Bone Tissue Engineering,” Materials (Basel)., vol. 13, no. 7, p. 1773, Apr. 2020. [5] E. Fukada and I. Yasuda, “On the Piezoelectric Effect of Bone,” J. Phys. Soc. Japan, vol. 12, no. 10, pp. 1158–1162, Oct. 1957.