| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Oliveira, Msa
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2013Shape memory polyurethanes reinforced with carbon nanotubescitations
- 2013The effect of carbon nanotubes on viscoelastic behaviour of biomedical grade ultra-high molecular weight polyethylenecitations
- 2011Enhanced UHMWPE Reinforced with MWCNT through Mechanical Ball-Millingcitations
- 2011The Use of Taguchi Technique to Optimize the Compression Moulding Cycle to Process Acetabular Cup Componentscitations
- 2011Performance of nanocrystalline diamond coated micromolding tools
- 2011Thermo-Mechanical Behaviour of Ultrahigh Molecular Weight Polyethylene-Carbon Nanotubes Composites under Different Cooling Techniquescitations
- 2010Tribological characterisation of carbon nanotubes/ultrahigh molecular weight polyethylene composites: the effect of sliding distancecitations
- 2010In vitro studies of multiwalled carbon nanotube/ultrahigh molecular weight polyethylene nanocomposites with osteoblast-like MG63 cellscitations
- 2009Tribology of biocompositescitations
- 2008Time-modulated chemical vapour deposition diamonf on mould making 2738 steelcitations
- 2008Dynamic Mechanical Analysis of Multi-Walled Carbon Nanotube/HDPE Compositescitations
- 2007Mechanical properties of high density polyethylene/carbon nanotube compositescitations
Places of action
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article
In vitro studies of multiwalled carbon nanotube/ultrahigh molecular weight polyethylene nanocomposites with osteoblast-like MG63 cells
Abstract
Carbon nanotubes are highly versatile materials; new applications using them are continuously being developed. Special attention is being dedicated to the possible use of multiwalled carbon nanotubes in biomaterials contacting with bone. However, carbon nanotubes are also controversial in regards to effects exerted on living organisms. Carbon nanotubes can be used to improve the tribological properties of polymer/composite materials. Ultrahigh molecular weight polyethylene (UHMWPE) is a polymer widely used in orthopedic applications that imply wear and particle generation. We describe here the response of human osteoblast-like MG63 cells after 6 days of culture in contact with artificially generated particles from both UHMWPE polymer and multiwalled carbon nanotubes (MWCNT)/UHMWPE nanocomposites. This novel composite has superior wear behavior, having thus the potential to reduce the number of revision hip arthroplasty surgeries required by wear failure of acetabular cups and diminish particle-induced osteolysis. The results of an in vitro study of viability and proliferation and interleukin-6 (IL-6) production suggest good cytocompatibility, similar to that of conventional UHMWPE (WST-1 assay results are reported as percentage of control +/- SD: UHMWPE = 96.19 +/- 7.92, MWCNT/UHMWPE = 97.92 +/- 8.29%; total protein: control = 139.73 +/- 10.78, UHMWPE = 137.07 +/- 6.17, MWCNT/UHMWPE = 163.29 +/- 11.81 mu g/mL; IL-6: control = 90.93 +/- 10.30, UHMWPE = 92.52 +/- 11.02, MWCNT/UHMWPE = 108.99 +/- 9.90 pg/mL). Standard cell culture conditions were considered as control. These results, especially the absence of significant elevation in the osteolysis inductor IL-6 values, reinforce the potential of this superior wear-resistant composite for future orthopedic applications, when compared to traditional UHMWPE.