| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Aseyev, Vladimir O.
University of Helsinki
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2024Clay Composites by In Situ Polymerization of Ionic Liquid-Based Dispersions
- 2023Amphoteric nano- and microgels with acrylamide backbone for potential application in oil recoverycitations
- 2023Clay Composites by In Situ Polymerization of Ionic Liquid-Based Dispersions
- 2022Well-dispersed clay in photopolymerized poly(ionic liquid) matrixcitations
- 2022Ophthalmic drug delivery system based on the complex of gellan and ofloxacincitations
- 2021Synthesis and characterization of novel thermo- and salt-sensitive amphoteric terpolymers based on acrylamide derivativescitations
- 2020Think Beyond the Corecitations
- 2016AuNP-Polymeric Ionic Liquid Composite Multicatalytic Nanoreactors for One-Pot Cascade Reactionscitations
- 2016Water-Dispersible Silica-Polyelectrolyte Nanocomposites Prepared via Acid-Triggered Polycondensation of Silicic Acid and Directed by Polycationscitations
- 2011Polyelectrolyte Brushes Grafted from Cellulose Nanocrystals Using Cu-Mediated Surface-Initiated Controlled Radical Polymerization.citations
- 2009Sorption of silicic acid from non-saturated aqueous solution by a complex of zinc ions with poly(vinylamine)citations
- 2004Complexation of DNA with Poly(methacryl oxyethyl trimethylammonium chloride) and Its Poly(oxyethylene) Grafted Analogue.citations
Places of action
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article
Ophthalmic drug delivery system based on the complex of gellan and ofloxacin
Abstract
Complex formation between a natural polysaccharide – gellan and an antimicrobial drug – ofloxacin was studied in aqueous solution. Conductimetric and potentiometric titration curves revealed that gellan and ofloxacin forms a water-soluble complex of composition 2:1 mol/mol stabilized by ionic and hydrogen bonds. The formation of the gellan-ofloxacin complex was confirmed by FTIR spectroscopy, dynamic light scattering, zeta-potential and thermogravimetric analysis. The average hydrodynamic size of the complex was found 307±5 nm and its zetapotential was negative and equal to -15 mV. Thin films of the gellan-ofloxacin complex, gelled in 0.3 wt.% of CaCl2, were used to study the release kinetics of ofloxacin in distilled water and phosphate buffer. The drug release kinetics evaluated by UV-Vis spectroscopy at λmax = 289 nm and calculated by the Ritger-Peppas model correspond to non-Fickian diffusion in distilled water and Case II transport (zero-order kinetics) in phosphate buffer. The cumulative release of ofloxacin from the gellan-ofloxacin films was equal to 96±2% and 36±2% in phosphate buffer and distilled water, respectively. It is expected that the gellan-ofloxacin complex is able to form in situ gel on the surface of the eye and to prolong the drug residence time in the tear fluid.