| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Emerson Coy, Phd, Dsc.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (38/38 displayed)
- 2024Ag, Cu, and Se-doped ultrasmall iron oxide colloidal gels: Revealing potential for photo/electrochemical applicationscitations
- 2024In vitro anticancer activity of melanin-like nanoparticles for multimodal therapy of glioblastomacitations
- 2023N-Doped HNT/TiO2 Nanocomposite by Electrospinning for Acetaminophen Degradationcitations
- 2023Highly regular laser-induced periodic silicon surface modified by MXene and ALD TiO2 for organic pollutants degradationcitations
- 2023Understanding the Photothermal and Photocatalytic Mechanism of Polydopamine Coated Gold Nanorodscitations
- 2023Control of Intermolecular Interactions toward the Production of Free-Standing Interfacial Polydopamine Filmscitations
- 2021Coaxial nanofibers of nickel/gadolinium oxide/nickel oxide as highly effective electrocatalysts for hydrogen evolution reactioncitations
- 2021Polydopamine Films with 2D-like Layered Structure and High Mechanical Resiliencecitations
- 2021Exploring the effect of BN and B-N bridges on the photocatalytic performance of semiconductor heterojunctions: Enhancing carrier transfer mechanismcitations
- 2021Atomic layer deposition of palladium coated TiO<inf>2</inf>/Si nanopillars: ToF-SIMS, AES and XPS characterization studycitations
- 2021Study of nanostructured ultra-refractory Tantalum-Hafnium-Carbide electrodes with wide electrochemical stability windowcitations
- 2021Fabrication of 3D printed antimicrobial polycaprolactone scaffolds for tissue engineering applicationscitations
- 2021Elaboration of porous alumina nanofibers by electrospinning and molecular layer deposition for organic pollutant removalcitations
- 2021Photoelectrocatalysis of paracetamol on Pd–ZnO/ N-doped carbon nanofibers electrodecitations
- 2021Insights and optimization of the structural and mechanical properties of TiWSiN coatings using the Taguchi methodcitations
- 2020Functionally graded nanocomposite materials for catalysis: From hard coatings to energy applicationscitations
- 2020Enhancing photocatalytic performance and solar absorption by schottky nanodiodes heterojunctions in mechanically resilient palladium coated TiO2/Si nanopillars by atomic layer depositioncitations
- 2020Nanocomposite Gel as Injectable Therapeutic Scaffold: Microstructural Aspects and Bioactive Propertiescitations
- 2020Synthesis and photoluminescence properties of hybrid 1D core-shell structured nanocomposites based on ZnO/polydopaminecitations
- 2020The pulsed laser ablation synthesis of colloidal iron oxide nanoparticles for the enhancement of TiO<inf>2</inf> nanotubes photo-activitycitations
- 2020Stabilization of complex orthorhombic o-Cr3C2 thin films under high energetic growth conditions: Experiments and calculationscitations
- 2020Investigation of polymer-derived Si–(B)–C–N ceramic/reduced graphene oxide composite systems as active catalysts towards the hydrogen evolution reactioncitations
- 2020Formation and photoluminescence properties of ZnO nanoparticles on electrospun nanofibers produced by atomic layer depositioncitations
- 2020Porous Silicon-Zinc Oxide Nanocomposites Prepared by Atomic Layer Deposition for Biophotonic Applicationscitations
- 2020Spectacular Oxygen Evolution Reaction Enhancement through Laser Processing of the Nickel-Decorated Titania Nanotubescitations
- 2020Method for probing flexoelectric response of free-standing cantilever beams by nanometric oscillations with nanoindentation techniquecitations
- 2018Titania nanotubes modified by a pyrolyzed metal-organic framework with zero valent iron centers as a photoanode with enhanced photoelectrochemical, photocatalytical activity and high capacitancecitations
- 2018Effect of nitrogen flow ratio on microstructure, mechanical and tribological properties of TiWSiN <inf>x</inf> thin film deposited by magnetron co-sputteringcitations
- 2017Ultra-low damping in lift-off structured yttrium iron garnet thin filmscitations
- 2017Robust tribo-mechanical and hot corrosion resistance of ultra-refractory Ta-Hf-C ternary alloy filmscitations
- 2017Second Harmonic Generation Response in Thermally reconstructed Multiferroic β′- Gd<inf>2</inf>(MoO<inf>4</inf>)<inf>3</inf> Thin Filmscitations
- 2017Nanocomposite Nb-Al-N coatings: Experimental and theoretical principles of phase transformationscitations
- 2017Silicon/TiO<inf>2</inf> core-shell nanopillar photoanodes for enhanced photoelectrochemical water oxidationcitations
- 2017Synthesis and characterization of nitride multilayerd coatings based on refractory metalscitations
- 2017Seeded Growth Synthesis of Au-Fe<inf>3</inf>O<inf>4</inf> Heterostructured Nanocrystals: Rational Design and Mechanistic Insightscitations
- 2017Multilayered vacuum-arc nanocomposite TiN/ZrN coatings before and after annealing: Structure, properties, first-principles calculationscitations
- 2015Study on Structural, Mechanical, and Optical Properties of Al<inf>2</inf>O<inf>3</inf>-TiO<inf>2</inf> Nanolaminates Prepared by Atomic Layer Depositioncitations
- 2014Tailoring mechanical properties and electrical conductivity of flexible niobium carbide nanocomposite thin filmscitations
Places of action
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article
In vitro anticancer activity of melanin-like nanoparticles for multimodal therapy of glioblastoma
Abstract
<jats:title>Abstract</jats:title><jats:p>Glioblastoma (GBM) is one of the most aggressive and hard to treat cancers. Traditional anti-cancer treatment methods have low efficiency and the lifespan after diagnosis is only 12–18 months. Brain tumor cells overexpress many proteins that play an important role in tumor progression and can be used as therapeutic targets. One of the promising approaches in cancer treatment is down-regulation of an extracellular matrix glycoprotein – Tenascin-C (TN-C) through RNA interference therapy. However, the effective delivery of double stranded RNA with one strand complementary to TN-C mRNA sequence is difficult due to rapid degradation by nucleases and low intracellular uptake. Polydopamine (PDA), a biomimetic polymer characterized by high biocompatibility and simple modification ability, is commonly used in nanobiomedicine to create a drug/gene delivery vehicle. Furthermore, photothermal characteristics of this polymer enable its application in photothermal therapy (PTT), which is a great option for cancer treatment. Here we synthesize PDA nanoparticles (NPs) coated with polyamidoamine dendrimers generation 3.0 (DD3.0) for therapeutic anti-TN-C RNA and doxorubicin delivery. As prepared PDA@DD3.0 NPs are then used in combined drug delivery, gene silencing, and PTT of GBM. The obtained materials are analyzed in terms of physicochemical and photothermal properties as well as their cytotoxicity, using human GBM cells. The results demonstrate that the obtained nanocarriers are effective non-viral vehicle for combined therapeutic approach for killing glioma cells <jats:italic>via</jats:italic> anti-TN-C RNA delivery and combined chemo-PTT therapy (CT-PTT). The application of PDA@DD3.0 NPs contributed to the 3-fold reduction in the proliferation rate of GBM cells, a decrease in the level of TN-C expression (by 30%) and a reduction in the number of viable cells by up to 20%.</jats:p>