• Shrestha, Ojaswee
• Pokhrel, Sushant
• Singh, Vinay Kumar
• Khanal, Puspa Raj
• Sapkota, Manisha
• Lamichhane, Anit
• Thapa, Tika Bahadur

Abstract

<jats:title>Abstract</jats:title><jats:p>Identifying and appropriately managing urinary tract infections (UTIs) among chronic kidney disease (CKD) patients are essential to reduce further disease complications and economic burden. Hence, this study aims to determine the prevalence of UTIs among CKD patients and study the antibiogram of the bacterial isolates. Four hundred eighty-two clean catch midstream urine samples were collected from CKD patients during the study period. The samples were cultured, and bacteria were isolated using standard microbiological techniques. Antibiotic susceptibility testing was performed by the Kirby–Bauer disc diffusion method following the Clinical and Laboratory Standards Institute guidelines. Of the 482 CKD patients, 15.8% were culture positive, and the majority was elderly aged group population. Most bacterial isolates were <jats:italic>Escherichia coli</jats:italic> 50%, followed by <jats:italic>Pseudomonas aeruginosa</jats:italic> 15.80%, <jats:italic>Enterococcus</jats:italic> species 15.80%, and <jats:italic>Klebsiella pneumoniae</jats:italic> 11.84%. The majority of bacteria were found to be resistant to beta-lactam antibiotics, ampicillin (94.67%), ceftriaxone (89.04%), cefotaxime (87.5%), and ceftazidime (84.0%), while polymyxin, colistin, vancomycin, meropenem, and imipenem were the most sensitive antibiotics. In our study, higher levels of antibiotic resistance were observed among urinary isolates. Therefore, our findings suggest clinicians to choose better antibiotic options to treat UTIs among CKD patients.</jats:p>

Topics

• susceptibility