| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Akhtar, Muhammad Nadeem
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Publications (2/2 displayed)
- 2023Synthesis of doped metal sulfide nanoparticles and their graphene reinforced nanohybrid for Pb(II) detectioncitations
- 2017Synthesis, characterization, thermal degradation and urease inhibitory studies of the new hydrazide based Schiff base ligand 2-(2-hydroxyphenyl)-3-{[(E)-(2-hydroxyphenyl)methylidene]amino}-2,3-dihydroquinazolin-4(1H)-onecitations
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article
Synthesis, characterization, thermal degradation and urease inhibitory studies of the new hydrazide based Schiff base ligand 2-(2-hydroxyphenyl)-3-{[(E)-(2-hydroxyphenyl)methylidene]amino}-2,3-dihydroquinazolin-4(1H)-one
Abstract
<jats:title>Abstract</jats:title><jats:p>The novel Schiff base ligand 2-(2-hydroxyphenyl)-3-{[(E)-(2-hydroxyphenyl)methylidene]amino}-2,3-dihydroquinazolin-4(1H)-one<jats:bold>(H-HHAQ)</jats:bold>derived from 2-aminobenzhydrazide was synthesized and characterized by elemental analyses, ES<jats:sup>+</jats:sup>-MS,<jats:sup>1</jats:sup>H and<jats:sup>13</jats:sup>C{<jats:sup>1</jats:sup>H}-NMR, and IR studies. The characterization of the ligand was further confirmed by single crystal analysis. The Schiff base ligand was complexed with metal ions like Co(II), Ni(II), Cu(II) and Zn(II) to obtain the bis-octahedral complexes. The ligand and its metal complexes were also studied for their urease inhibitory activities. All the tested compounds show medium to moderate activities for the enzyme, whereas the copper based complex was found to be much more active against urease with an IC<jats:sub>50</jats:sub><jats:bold>=</jats:bold>0.3 ± 0.1 μM±SEM, which is even more potent than the standard thiourea. The IC<jats:sub>50</jats:sub>of the cobalt complex was 43.4±1.2 μM±SEM, whereas that of the nickel complex was 294.2±5.0 μM±SEM. The ligand<jats:bold>H-HHAQ</jats:bold>and the zinc complex were inactive against the tested enzyme.</jats:p>