• Arbeiter, Daniela
• Schmitz, Klaus-Peter
• Paasche, Gerrit
• Oschatz, Stefan
• Lebahn, Kerstin
• Lenarz, Thomas
• Stöffler, Kerstin
• Reske, Thomas
• Grabow, Niels

Abstract

<jats:title>Abstract</jats:title><jats:p>The novel concept of stenting the Eustachian tube was established to provide an effective and safe therapy of Eustachian tube dysfunction. Biodegradable polymer stents are being developed to restore impaired tube function. As the supporting effect may be required for different time periods, PLA-co-PEG copolymers, PLLGA, PDLLA and PDS, having shorter degradation times compared to PLLA, were evaluated as potential stent materials. Since tensile tests and thermal analyses of solvent cast films from PLA-co-PEG copolymers showed comparable properties to PLLA, stent samples were manufactured from these materials. Mechanical stent testing revealed an increase of elastic recoil and slight decrease of collapse pressure compared to PLLA. In a short term accelerated degradation study a considerable percentage molar mass reduction and an increasing degree of crystallinity depending on PEG content was found. Based on the results obtained, the tested polymers offer a promising, faster degradable alternative to the established stent material PLLA.</jats:p>

Topics

• copolymer
• crystallinity