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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Petrović, Božana
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2024The intensity of subacute local biological effects after the implantation of ALBO-OS dental material based on hydroxyapatite and poly(lactide-co-glycolide): <i>in vivo</i> evaluation in rats
- 2022Detailed phisyco-chemical characterization of the multilayered thin films based on titanium oxynitride and copper doped titanium nitride obtained by different PVD techniquescitations
- 2019The main characteristics and application of the shape memory alloys in orthodontics and endodonticscitations
- 2017Informative article. Scaffold in bone tissue engineeringcitations
- 2011Nucleation of biomimetic hydroxyapatitecitations
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article
The intensity of subacute local biological effects after the implantation of ALBO-OS dental material based on hydroxyapatite and poly(lactide-co-glycolide): <i>in vivo</i> evaluation in rats
Abstract
<jats:title>Abstract</jats:title><jats:sec id="j_bmt-2023-0640_abs_001"><jats:title>Objectives</jats:title><jats:p>This study aimed to evaluate the intensity of the subacute local biological effects after implantation and osseoconductive potential of novel hydroxyapatite-based bone substitute coated with poly (lactide-co-glycolide), named ALBO-OS, in comparison to Bio-Oss<jats:sup>®</jats:sup>.</jats:p></jats:sec><jats:sec id="j_bmt-2023-0640_abs_002"><jats:title>Methods</jats:title><jats:p>Fifteen male Wistar rats, randomly assigned into groups: 10, 20, and 30 days (n꞊5), were subcutaneously implanted with ALBO-OS and Bio-Oss<jats:sup>®</jats:sup>. Furthermore, artificially made bone defects on both rat’s tibias were implanted with experimental materials. Unimplanted defects represented negative control. After the animals’ euthanizing, tissue samples were prepared and analyzed histologically and histomorphometrically.</jats:p></jats:sec><jats:sec id="j_bmt-2023-0640_abs_003"><jats:title>Results</jats:title><jats:p>Normal healing of the epithelial tissue was observed, with no signs of infection or necrosis. Minimal vascular congestion was noted immediately around the graft, with no signs of tissue oedema, with a minimal capsule thickness. The applied material did not cause an inflammatory response (IR) of significant intensity, and 20 days after implantation, the IR was mainly assessed as minimal. The tibial specimen showed that ALBO-OS has good osseoconductive potential, similar to Bio-Oss<jats:sup>®</jats:sup>, as well as low levels of acute and subacute inflammation.</jats:p></jats:sec><jats:sec id="j_bmt-2023-0640_abs_004"><jats:title>Conclusions</jats:title><jats:p>The tested material exhibits satisfying biocompatibility, similar to Bio-Oss<jats:sup>®</jats:sup>.</jats:p></jats:sec>