| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Semenova, Yuliya
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (7/7 displayed)
- 2022Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patientscitations
- 2018A comprehensive experimental study of whispering gallery modes in a cylindrical microresonator excited by a tilted fiber tapercitations
- 2017Strain-induced spectral tuning of the whispering gallery modes in a cylindrical micro-resonator formed by a polymer optical fibercitations
- 2012Chalcogenide microsphere fabricated from fiber tapers using contact with a high-temperature ceramic surfacecitations
- 2011Stress induced in optical fiber sensors embedded in composite materials by the lamination process
- 2011Lead silicate glass microsphere resonators with absorption-limited Qcitations
- 2010Macro-bend optical fiber linear displacement sensorcitations
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article
Gene polymorphisms and serum levels of BDNF and CRH in vitiligo patients
Abstract
<jats:sec id="sec001"> <jats:title>Background</jats:title> <jats:p>Vitiligo is one of the most common hypomelanoses, in which the destruction of functioning melanocytes causes depigmentation of the skin, hair and mucous membranes. The genes encrypting brain-derived neurotrophic factor (BDNF) and corticotropin releasing hormone (CRH) might be the conceivable contributors to the development of vitiligo. This study was aimed at investigation of the serum levels of BDNF and CRH as well as their selected single nucleotide polymorphisms (SNPs) in vitiligo patients in comparison with the healthy controls.</jats:p> </jats:sec> <jats:sec id="sec002"> <jats:title>Methods</jats:title> <jats:p>The cross-sectional study was carried out between October 2020 and June 2021 in 93 vitiligo patients (age range from 23 to 48 years) and 132 healthy controls (age range from 24 to 52 years). The psychological status of study participants was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) scale. Serum levels of BDNF and CRH were measured with the help of a commercially available sandwich enzyme-linked immunosorbent assay (ELISA) kit. Genotyping for the rs11030094 polymorphism of the <jats:italic>BDNF</jats:italic> gene and for the rs242924 polymorphism of the corticotropin releasing hormone receptor 1 <jats:italic>(CRH-R1)</jats:italic> gene was performed by a real-time polymerase chain reaction (PCR).</jats:p> </jats:sec> <jats:sec id="sec003"> <jats:title>Results</jats:title> <jats:p>There was a significant relationship between the <jats:italic>CRH-R1</jats:italic> rs242924 and <jats:italic>BDNF</jats:italic> rs11030094 polymorphisms and vitiligo. Moreover, serum levels of neurotransmitters differed significantly between vitiligo and control groups and were associated with the <jats:italic>CRH-R1</jats:italic> rs242924 and <jats:italic>BDNF</jats:italic> rs11030094 SNPs.</jats:p> </jats:sec> <jats:sec id="sec004"> <jats:title>Conclusions</jats:title> <jats:p>Our findings demonstrated the association between <jats:italic>CRH-R1</jats:italic> rs242924 and <jats:italic>BDNF</jats:italic> rs11030094 polymorphisms and vitiligo. Further studies need to be carried out in vitiligo patients to confirm the results observed.</jats:p> </jats:sec>