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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Hynowska, Anna
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (8/8 displayed)
- 2016Effect of surface modifications of Ti40Zr10Cu38Pd12 bulk metallic glass and Ti-6Al-4V alloy on human osteoblasts in vitro biocompatibilitycitations
- 2016Effect of surface modifications of Ti40Zr10Cu38Pd12 bulk metallic glass and Ti-6Al-4V alloy on human osteoblasts in vitro biocompatibilitycitations
- 2015Nanostructured Ti-Zr-Pd-Si-(Nb) bulk metallic composites : novel biocompatible materials with superior mechanical strength and elastic recoverycitations
- 2014In vitro biocompatibility assessment of Ti40Cu38Zr10Pd12 bulk metallic glasscitations
- 2014Biocompatible Ti-based metallic glasses and nanocomposite materials
- 2014Biocompatible Ti-based metallic glasses and nanocomposite materials
- 2013Novel Ti-Zr-Hf-Fe nanostructured alloy for biomedical applicationscitations
- 2013Novel Ti-Zr-Hf-Fe Nanostructured Alloy for Biomedical Applicationscitations
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article
Effect of surface modifications of Ti40Zr10Cu38Pd12 bulk metallic glass and Ti-6Al-4V alloy on human osteoblasts in vitro biocompatibility
Abstract
© 2016 Blanquer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The use of biocompatible materials, including bulk metallic glasses (BMGs), for tissue regeneration and transplantation is increasing. The good mechanical and corrosion properties of Ti40Zr10Cu38Pd12 BMG and its previously described biocompatibility makes it a potential candidate for medical applications. However, it is known that surface properties like topography might play an important role in regulating cell adhesion, proliferation and differentiation. Thus, in the present study, Ti40Zr10Cu38Pd12 BMG and Ti6-Al-4V alloy were surface-modified electrochemically (nanomesh) or physically (microscratched) to investigate the effect of material topography on human osteoblasts cells (Saos-2) adhesion, proliferation and differentiation. For comparative purposes, the effect of mirror-like polished surfaces was also studied. Electrochemical treatments led to a highly interconnected hierarchical porous structure rich in oxides, which have been described to improve corrosion resistance, whereas microscratched surfaces showed a groove pattern with parallel trenches. Cell viability was higher than 96% for the three topographies tested and for both alloy compositions. In all cases, cells were able to adhere, proliferate and differentiate on the alloys, hence indicating that surface topography plays a minor role on these processes, although a clear cell orientation was observed on microscratched surfaces. Overall, our results provide further evidence that Ti40Zr10Cu38Pd12 BMG is an excellent candidate, in the present two topographies, for bone repair purposes.