| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Den Toonder, Jaap M. J.
Eindhoven University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (27/27 displayed)
- 2023Fully Transparent, Ultrathin Flexible Organic Electrochemical Transistors with Additive Integration for Bioelectronic Applicationscitations
- 2023Single Hydrogel Particle Mechanics and Dynamics Studied by Combining Capillary Micromechanics with Osmotic Compressioncitations
- 2023Round lumen-based microfluidic devices for modelling cancer metastasis
- 2023Nanomagnetic Elastomers for Realizing Highly Responsive Micro- and Nanosystemscitations
- 2023Nanomagnetic Elastomers for Realizing Highly Responsive Micro- and Nanosystemscitations
- 2022A Prototype System with Custom-Designed RX ICs for Contrast-Enhanced Ultrasound Imagingcitations
- 2017Microfluidic magnetic bead conveyor beltcitations
- 2017Magnetofluidic conveyor belt
- 2014Monocytic cells become less compressible but more deformable upon activationcitations
- 2012Magnetically actuated artificial cilia : the effect of fluid inertiacitations
- 2011Magnetically-actuated artificial cilia for microfluidic propulsioncitations
- 2009Numerical simulation of flat-tip micro-indentation of glassy polymers: influence of loading speed and thermodynamic statecitations
- 2007Micro-mechanical testing of SiLK by nanoindentation and substrate curvature techniquescitations
- 2006Indentation: the experimenter's holy grail for small-scale polymer characterization?
- 2006Buckle morphology of compressed inorganic thin layers on a polymer substratecitations
- 2005Viscoelastic characterization of low-dielectric-constant SiLK films using nano-indentation in combination with finite element modelingcitations
- 2005Finite thickness influence on spherical and conical indentation on viscoelastic thin polymer filmcitations
- 2005On factors affecting the extraction of elastic modulus by nanoindentation of organic polymer filmscitations
- 2004Mechanical characterization of SiLK by nanoindentation and substrate curvature techniquescitations
- 2004Optimization of mechanical properties of thin free-standing metal films for RF-MEMScitations
- 2004Optimization of mechanical properties of thin free-standing metal films for RF-MEMScitations
- 2003Residual stresses in multilayer ceramic capacitors: measurement and computationcitations
- 2003Influence of visco-elasticity of low-k dielectrics on thermo-mechanical behavior of dual damascene processcitations
- 2002Fracture toughness and adhesion energy of sol-gel coatings on glasscitations
- 2002Measuring mechanical properties of coatings : a methodology applied to nano-particle-filled sol-gel coatings on glasscitations
- 2000Determination of the elastic modulus and hardness of sol-gel coatings on glass: influence of indenter geometrycitations
- 2000The effect of friction on scratch adhesion testing : application to a sol-gel coating on polypropylenecitations
Places of action
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article
Monocytic cells become less compressible but more deformable upon activation
Abstract
AimsMonocytes play a significant role in the development of atherosclerosis. During the process of inflammation, circulating monocytes become activated in the blood stream. The consequent interactions of the activated monocytes with the blood flow and endothelial cells result in reorganization of cytoskeletal proteins, in particular of the microfilament structure, and concomitant changes in cell shape and mechanical behavior. Here we investigate the full elastic behavior of activated monocytes in relation to their cytoskeletal structure to obtain a better understanding of cell behavior during the progression of inflammatory diseases such as atherosclerosis. Methods and Results The recently developed Capillary Micromechanics technique, based on exposing a cell to a pressure difference in a tapered glass microcapillary, was used to measure the deformation of activated and non-activated monocytic cells. Monitoring the elastic response of individual cells up to large deformations allowed us to obtain both the compressive and the shear modulus of a cell from a single experiment. Activation by inflammatory chemokines affected the cytoskeletal organization and increased the elastic compressive modulus of monocytes with 73–340%, while their resistance to shape deformation decreased, as indicated by a 25–88% drop in the cell’s shear modulus. This decrease in deformability is particularly pronounced at high strains, such as those that occur during diapedesis through the vascular wall. ConclusionOverall, monocytic cells become less compressible but more deformable upon activation. This change in mechanical response under different modes of deformation could be important in understanding the interplay between the mechanics and function of these cells. In addition, our data are of direct relevance for computational modeling and analysis of the distinct monocytic behavior in the circulation and the extravascular space. Lastly, an understanding of the changes of monocyte mechanical properties will be important in the development of diagnostic tools and therapies concentrating on circulating cells.