| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Anderson, Pd Patrick
Eindhoven University of Technology
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (50/50 displayed)
- 2024Numerical simulation of fiber orientation kinetics and rheology of fiber-filled polymers in uniaxial extensioncitations
- 2024Fiber-induced crystallization in elongational flowscitations
- 2024In situ experimental investigation of fiber orientation kinetics during uniaxial extensional flow of polymer compositescitations
- 2024A monolithic numerical model to predict the EMI shielding performance of lossy dielectric polymer nanocomposite shields in a rectangular waveguidecitations
- 2023Deformation kinetics of single-fiber polypropylene composites
- 2023Shear-Induced Structure Formation in MAH-g-PP Compatibilized Polypropylenescitations
- 2022Laser sintering of PA12 particles studied by in-situ optical, thermal and X-ray characterizationcitations
- 2022Numerical Modeling of the Blend Morphology Evolution in Twin-Screw Extruderscitations
- 2022Constitutive framework for rheologically complex interfaces with an application to elastoviscoplasticitycitations
- 2021Computational interfacial rheologycitations
- 2021Numerical simulations of the polydisperse droplet size distribution of disperse blends in complex flowcitations
- 2020Numerical analysis of the crystallization kinetics in SLScitations
- 2020On the validity of 2D analysis of non-isothermal sintering in SLScitations
- 2020A filament stretching rheometer for in situ X-ray experimentscitations
- 2020Polymer spheres
- 2020Polarization modulated infrared spectroscopycitations
- 2020Transient dynamics of cold-rolled and subsequently thermally rejuvenated atactic-polystyrene using broadband dielectric spectroscopycitations
- 2019Hydrostatic stress as indicator for wear initiation in polymer tribology
- 2019Hydrostatic stress as indicator for wear initiation in polymer tribologycitations
- 2019Effect of low-temperature physical aging on the dynamic transitions of atactic polystyrene in the glassy statecitations
- 2019A novel experimental setup for in-situ optical and X-ray imaging of laser sintering of polymer particlescitations
- 2019A novel experimental setup for in-situ optical and X-ray imaging of laser sintering of polymer particles
- 2019Simulation of bubble growth during the foaming process and mechanics of the solid foamcitations
- 2019Modelling flow induced crystallization of IPPcitations
- 2019Temperature dependent two-body abrasive wear of polycarbonate surfaces
- 2019Temperature dependent two-body abrasive wear of polycarbonate surfacescitations
- 2019Laser sintering of polymer particle pairs studied by in-situ visualization
- 2019Laser sintering of polymer particle pairs studied by in-situ visualizationcitations
- 2018Contact mechanics of high-density polyethylene: Effect of pre-stretch on the frictional response and the onset of wear
- 2018Contact mechanics of high-density polyethylene: Effect of pre-stretch on the frictional response and the onset of wearcitations
- 2018Temperature-dependent sintering of two viscous particlescitations
- 2018Contact mechanics of polyolefins: effect of pre-stretch on the frictional response and the onset of wear
- 2018Designing multi-layer polymeric nanocomposites for EM shielding in the X-bandcitations
- 2017Future nanocomposites : exploring multifunctional multi-layered architectures
- 2017Experimental setup for in situ visualization studies of laser sintering of polymer particles
- 2017Next generation multi-material 3D food printer concept
- 2017Sintering of two viscoelastic particles: a computational approachcitations
- 2016Predicting the fountain flow instability
- 2016Long term performance of fiber-reinforced polymers
- 2014Monocytic cells become less compressible but more deformable upon activationcitations
- 2010Residual stresses in gas-assisted injection moldingcitations
- 2009Scale-down of mixing equipment : microfluidics
- 2009Model development and validation of crystallization behavior in injection molding prototype flowscitations
- 2008Transient interfacial tension of partially miscible polymerscitations
- 2006Viscoelastic effects in multilayer polymer extrusion
- 2006On the streamfunction-vorticity formulation in sliding bi-period frames : application to bulk behavior for polymer blendscitations
- 2006Two component injection molding of phase separating blendscitations
- 2006Application of mortar elements to diffuse-interface methodscitations
- 2003Diffuse interface modeling of the morphology and rheology of immiscible polymer blendscitations
- 2003Diffuse interface modelling of the rheology of immiscible polymer blends
Places of action
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article
Monocytic cells become less compressible but more deformable upon activation
Abstract
AimsMonocytes play a significant role in the development of atherosclerosis. During the process of inflammation, circulating monocytes become activated in the blood stream. The consequent interactions of the activated monocytes with the blood flow and endothelial cells result in reorganization of cytoskeletal proteins, in particular of the microfilament structure, and concomitant changes in cell shape and mechanical behavior. Here we investigate the full elastic behavior of activated monocytes in relation to their cytoskeletal structure to obtain a better understanding of cell behavior during the progression of inflammatory diseases such as atherosclerosis. Methods and Results The recently developed Capillary Micromechanics technique, based on exposing a cell to a pressure difference in a tapered glass microcapillary, was used to measure the deformation of activated and non-activated monocytic cells. Monitoring the elastic response of individual cells up to large deformations allowed us to obtain both the compressive and the shear modulus of a cell from a single experiment. Activation by inflammatory chemokines affected the cytoskeletal organization and increased the elastic compressive modulus of monocytes with 73–340%, while their resistance to shape deformation decreased, as indicated by a 25–88% drop in the cell’s shear modulus. This decrease in deformability is particularly pronounced at high strains, such as those that occur during diapedesis through the vascular wall. ConclusionOverall, monocytic cells become less compressible but more deformable upon activation. This change in mechanical response under different modes of deformation could be important in understanding the interplay between the mechanics and function of these cells. In addition, our data are of direct relevance for computational modeling and analysis of the distinct monocytic behavior in the circulation and the extravascular space. Lastly, an understanding of the changes of monocyte mechanical properties will be important in the development of diagnostic tools and therapies concentrating on circulating cells.