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Marjańska, Małgorzata
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article
Faster Metabolite 1H Transverse Relaxation in the Elder Human Brain
Abstract
<p><sup>1</sup>H magnetic resonance spectroscopy (MRS) is unique among imaging modalities because signals from several metabolites are measured during a single examination period. Each metabolite reflects a distinct intracellular process. Furthermore transverse (T<sub>2</sub>) relaxation times probe the viability of the cell microenvironment, e.g., the viscosity of the cellular fluids, the microscopic susceptibility distribution within the cells, and the iron content. In this study, T<sub>2</sub>s of brain metabolites were measured in the occipital lobe of eighteen young and fourteen elderly subjects at a field strength of 4 tesla. The T<sub>2</sub>s of N-acetylaspartate, total creatine, and total choline were 23%, 16% and 10% shorter in elderly than in young subjects. The findings of this study suggest that noninvasive detection of T<sub>2</sub> provides useful biological information on changes in the cellular microenvironment that take place during aging.</p>