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Naji, M. |
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Motta, Antonella |
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Aletan, Dirar |
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Mohamed, Tarek |
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Ertürk, Emre |
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Taccardi, Nicola |
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Kononenko, Denys |
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Petrov, R. H. | Madrid |
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Alshaaer, Mazen | Brussels |
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Bih, L. |
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Casati, R. |
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Muller, Hermance |
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Kočí, Jan | Prague |
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Šuljagić, Marija |
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Kalteremidou, Kalliopi-Artemi | Brussels |
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Azam, Siraj |
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Ospanova, Alyiya |
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Blanpain, Bart |
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Ali, M. A. |
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Popa, V. |
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Rančić, M. |
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Ollier, Nadège |
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Azevedo, Nuno Monteiro |
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Landes, Michael |
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Rignanese, Gian-Marco |
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Gergely, Csilla
University of Montpellier
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (9/9 displayed)
- 2019Peptide-route functionalization of chalcogenide films
- 2018Elaboration and Characterization of Porous Silicon multilayer for biomaterial applications
- 2018Elaboration and Characterization of Porous Silicon multilayer for biomaterial applications
- 2014Morphology and nanomechanics of mice sensory neurons following peripheral nerve injury
- 2014Sprayed Cells and Polyelectrolyte Films for Biomaterial Functionalization: The Influence of Physical PLL-PGA Film Treatments on Dental Pulp Cell Behaviorcitations
- 2013Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injurycitations
- 2013Nanomechanics of mice sensory neurons as measured by atomic force microscopy.
- 2011Dental Pulp Stem Cells Adhesion/Proliferation On Porous Silicon Scaffold
- 2008Specific peptide for functionalization of GaN - art. no. 699121
Places of action
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article
Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injury
Abstract
A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re-growth. Our differential interference contrast microscopy and immunocytochemistry results show that conditioned axotomy, induced by sciatic nerve injury, did not increase somatic size of adult lumbar sensory neurons from mice dorsal root ganglia sensory neurons but promoted the appearance of larger neurites and growth cones. Using atomic force microscopy on live neurons, we investigated whether membrane mechanical properties of growth cones of axotomized neurons were modified following sciatic nerve injury. Our data revealed that neurons having a regenerative growth were characterized by softer growth cones, compared to control neurons. The increase of the growth cone membrane elasticity suggests a modification in the ratio and the inner framework of the main structural proteins.