693.932 PEOPLE
| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Winkler, Anja
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (51/51 displayed)
- 2024Manufacture and deformation angle control of a two-direction soft actuator integrated with SMAs
- 2024Manufacturing, development and control of a two-way 3D printed soft actuator actuated with SMAscitations
- 2024Development of a smart implant for monitoring spinal stabilization using a rod-integrated measurement system
- 2024Experimental and numerical analysis of bending performance for a glass-epoxy composite with integrated sheet-shaped shape memory alloy actuator elementscitations
- 2024Closed-loop control of a 3D printed soft actuator with integrated flex sensors and SMA wirescitations
- 2024A novel selective prostaglandin-receptor EP4-agonist promotes spinal fusion in rats
- 2023Experimental and numerical investigation of 3D printed elastomeric composite with integrated SMA actuatorcitations
- 2023Experimental analysis of the influence of thermoplastic veils doped with nanofillers on the thermal properties of fibre-reinforced composites
- 2023Integration of sensors in sandwich composites for the detection of structural damage
- 2023Spatially resolved strain measurement at meter scale using a carbon fiber based strain sensor and artificial neural networks
- 2023Numerical investigation of the magnetic alignment of Fe-Co-coated single reinforcement fiberscitations
- 2022Integration von Sensorik in duroplastische Sandwichverbunde zur Erkennung von strukturellen Schäden
- 2022Calibration of piezoresistive shape-memory alloy strain sensorscitations
- 2022Numerical investigation of the orientability of single reinforcement fibers in polymer matricescitations
- 2022Synthese des Verformungsverhaltens von nachgiebigen Elementen mittels Phasenportrait-Methode
- 2022Modeling electrical conductivity of metal meshes for predicting shielding effectiveness in magnetic fields of wireless power transfer systemscitations
- 2021Load monitoring for sailplanes utilizing an innovative carbon fibre-based, spatially resolved strain sensor
- 2021Sound field mapping using automated delta kinematics
- 2021Delamination behaviour of embedded polymeric sensor and actuator carrier layers in epoxy based cfrp laminates—a study of energy release ratescitations
- 2021T-EXoSuit - Textilbasiertes Exoskelett mit individuell einstellbarem graduellem Bewegungswiderstand und User Interface zur präventiven und rehabilitativen Unterstützung des Bewegungsapparats
- 2018Development of a series capable production process for fiber-reinforced composites with thermoplastic matrices and material-integrated piezoceramic modulescitations
- 2018Tailored embeddable sensor-actuator layers for CFRP aerospace structures
- 2018Polymer analyses for an adapted process design of the pipe-extrusion of polyetherimidecitations
- 2018Development of material-integrated actuator-sensor-arrays for obstacle sensingcitations
- 2018High-volume production-compatible technologies for light metal and fiber composite-based components with integrated piezoceramic sensors and actuatorscitations
- 2017Experimentelle und numerische Untersuchungen von textilverstärkten thermoplastischen Verbundwerkstoffen mit eingebetteten piezoelektrischen Sensor-Aktor-Arrays hinsichtlich der gerichteten Abstrahlung von akustischen Wellen
- 2017Piezokeramik in Faserverbund - Großserienfähige Fertigungstechnologien
- 2017Funktionsintegration auf Werkstoff- und Systemebene
- 2017Verfahren zur Herstellung von mechanisch-elektrischen Fügeverbindungen zwischen mindestens zwei elektrisch leitenden Verbunden eines Verbundsystems und multifunktionales Verbundsystem
- 2017Investigation on Laser assisted wire bonding by means of droplet joining of novel thermoplastic-compatiple piezoceramic modules
- 2016Aktive faserverstärkte Thermoplastverbunde mit materialhomogen integrierten Piezokeramikmodulen – ein Ausblickcitations
- 2015Investigations on laser based joining of novel thermoplastic compatible piezoceramic modules
- 2015Active fibre-reinforced thermoplastic composite components with embedded sensor-actuator arrays
- 2015Herstellung und Charakterisierung von Faserverbundstrukturen mit integrierten piezoelektrischen Wandlerarrays für die gerichtete Abstrahlung von Ultraschall
- 2013Thermal analysis of 3D-CF/Al-MMC by means of DSC and dilatometry tests
- 2013Integration of thermoplastic compatible piezoceramic modules into fibre reinforced components
- 2013Experimentelle Studien zur Entwicklung einer neuartigen e-preforming-Technologie für die großseriengerechte Fertigung aktiver Thermoplastverbundstrukturen
- 2013Process chain modelling and analysis for the high volume production of thermoplastic composites with embedded piezoceramic modulescitations
- 2013Fibre reinforced composite structures based on thermoplastic matrices with embedded piezoceramic modules
- 2011Characterization of novel thermoplastic-compatible piezoceramic modules for function integrative composite structures
- 2011Detection of material integrated conductors for connective riveting of function-integrative textile-reinforced thermoplastic composites
- 2011Studien zur prozessimmanenten Online-Polarisation heißpresstechnisch integrierter piezokeramischer Aktuatoren in Thermoplastverbundstrukturen
- 2011Static and dynamic testing of textile-reinforced composite compliant structures under shear-force-free bending load
- 2011Process development for high volume manufacture of thermoplastic composites with integrated piezoceramic modules
- 2011Novel approaches for the determination of the process specific polarization of piezoceramic modules embedded in thermoplastic composites
- 2010Untersuchungen zur Charakterisierung des gradierten Faseranteils im Randbereich warmgeformter Löcher in textilverstärkten Thermoplastbauteilen
- 2009Untersuchungen zur Entwicklung robuster Fertigungsprozesse für die Herstellung aktiver Thermoplastverbundbauteile mit integrierten neuartigen thermoplastkompatiblen Piezokeramik-Modulen (TPM)
- 2009Processing studies for the development of a robust manufacture process for active composite structures with matrix-adapted piezoceramic modules
- 2009Entwicklung einer Fertigungstechnologie für faserverstärkte Thermoplastverbunde mit integrierten Piezokeramik-Modulen
- 2008Robust manufacture of fibre-reinforced composites with embedded piezoceramic modules for automotive applications
- 2007Innovative lightweight solutions by textile-reinforced thermoplastic composites with embedded material-adapted piezo-ceramic actuator modules
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article
A novel selective prostaglandin-receptor EP4-agonist promotes spinal fusion in rats
Abstract
A novel EP4 selective agonist (KMN-159) was developed [1] and has been proven that it can act as an osteopromotive factor to repair critical-size femoral bone defects in rats at a dose-dependent manner [2]. Based on its osteopromotive properties, we hypothesized that KMN-159 could also aid in bone formation for spinal fusion. Therefore, the aim of this study was to investigate its spinal fusion effect in a dorsolateral spinal fusion model in rats. This study was performed on 192, 10-week-old male Wistar rats. The rats were randomized into 8 groups (n = 12 per group): 1) SHAM (negative control), 2) MCM (scaffold only), 3) MCM + 20 µg BMP-2 (positive control), 4-8) MCM + 0.2, 2, 20, 200 or 2000 µg KMN-159. A posterolateral intertransverse process spinal fusion at L4 to L5 was performed bilaterally by implanting group dependent scaffolds (see above) or left empty in the SHAM group (protocol no. 25-5131/474/38). Animals were euthanized after 3 weeks and 6 weeks for µCT and biomechanical testing analysis. The results showed that KMN-159 promoted new bone formation in a dose-dependent manner at 3 weeks and 6 weeks as verified by µCT. The biomechanical testing showed that the dose of 20, 200 and 2000 µg KMN-159 groups obtained comparable strength with BMP-2 group, which higher than SHAM, MCM and lower doses of 0.2 and 2 µg KMN-159 groups. In conclusion, KMN-159 could be a potential replacement of BMP-2 as a novel osteopromotive factor for spinal fusion. Acknowledgements: We are grateful to Ulrike Heide, Anna-Maria Placht (assistance with surgeries) as well as Suzanne Manthey & Annett Wenke (histology).