| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Broberg, Karin
Karolinska Institutet
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2024OS03-11 Exposure to PFAS and associated toxicity in workers exposed to hexavalent chromium – a cross-sectional study within the SafeChrom project
- 2024P-205 THE SAFECHROM PROJECT - EVIDENCE FROM A CROSS-SECTIONAL STUDY SHOWS THAT HEXAVALENT CHROMIUM IS STILL A CONCERN IN SWEDEN
- 2023Manganese efflux transporter SLC30A10 missense polymorphism T95I associated with liver injury retains manganese efflux activitycitations
- 2021Toxicity of stainless and mild steel particles generated from gas–metal arc welding in primary human small airway epithelial cellscitations
- 2013Polymorphisms in Iron Homeostasis Genes and Urinary Cadmium Concentrations among Nonsmoking Women in Argentina and Bangladesh.citations
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article
Polymorphisms in Iron Homeostasis Genes and Urinary Cadmium Concentrations among Nonsmoking Women in Argentina and Bangladesh.
Abstract
BACKGROUND: Cadmium (Cd) is a human toxicant and carcinogen. Genetic variation might affect long-term accumulation. Cadmium is absorbed by iron transporters. OBJECTIVES: To evaluate the impact of iron homeostasis genes (divalent metal transporter 1 SLC11A2; transferrin TF; transferrin receptors TFR2 and TFRC; ferroportin SLC40A1) on Cd accumulation. METHODS: Subjects were non-smoking women living in the Argentinean Andes [n=172; median urinary Cd (U-Cd)=0.24 µg/L] and Bangladesh (n=359; U-Cd=0.53 µg/L) with Cd exposure mainly from food. U-Cd and Cd in whole blood or erythrocytes (Ery-Cd) was measured by ICPMS. Fifty polymorphisms were genotyped by Sequenom. Gene expression was measured in whole blood (n=72) with Illumina DirectHyb HumanHT-12 v4.0. RESULTS: TFRC rs3804141 was consistently associated with U-Cd. In the Andeans, mean U-Cd concentrations were 22% (95% CI: -2, 51%) and 56% (95% CI: 10, 120%) higher in women with GA and AA genotypes, respectively, relative to women with the GG genotype. In Bangladesh, mean U-Cd concentrations were 22% (95% CI: 1, 48%) and 58% (95% CI: -3, 157%) higher in women with GA and AA versus GG genotype, respectively (adjusted for age and plasma ferritin in both groups; p for trend 0.006 [Andes] and 0.009 [Bangladesh]). TFRC expression in blood was negatively correlated with plasma ferritin (rS=-0.33, p=0.006), and positively correlated with Ery-Cd (significant at ferritin concentrations <30 µg/L only, rS=0.40, p=0.046). Rs3804141 did not modify these associations or predict TFRC expression. Cd was not consistently associated with any of the other polymorphisms evaluated. CONCLUSIONS: One TFRC polymorphism was associated with urine Cd concentration, a marker of Cd accumulation in the kidney, in two very different populations. The consistency of the findings supports the possibility of a causal association.