• V., Anil Kumar K.
• Rani, Swaroopa
• Rao, Suguna
• S., Girish B.
• Johns, Joel M.
• Kumar, Anil

Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Urolithiasis is a painful condition and current treatment doesn’t assure the prevention of recurrence. This research aims to demonstrate the scientific reliability of Chloroform leaf extract of <jats:italic>Flemingia Strobilifera</jats:italic> R.Br. (CEFS) for antiurolithiatic activity using ethylene glycol-induced urolithiasis model.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Ethylene glycol (EG) was used to induce hyperoxaluria in male Wistar rats. The rats were grouped into 7-groups containing six each. Group I and II served as negative and positive control, group III received standard treatment, whereas Group IV to VII served as testing groups. CEFS of 30 mg/kg body-weight and 60 mg/kg body-weight was used as a preventive and curative regimen. The urine biochemistry was analysed for the presence of calcium, magnesium, phosphate, and oxalate. The rats were sacrificed for histopathological examination and LDH detection. The 24-hours urine volume was increased in both EG-treated groups as well as CEFS-treated groups, indicating the diuretic activity of plant. CEFS dose-dependently inhibited urine excretion of phosphate, calcium, and oxalate compared to the positive-control group. The histopathological examination of CEFS-treated rats’ kidneys had reduced loss of renal structure and lessened deposition of calcium oxalate crystals.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>CEFS exhibited significant antiurolithiatic activity by reducing supersaturation of urine and excretion of stone forming components.</jats:p></jats:sec>

Topics

• Deposition
• impedance spectroscopy
• Magnesium
• Magnesium
• forming
• Calcium
• size-exclusion chromatography