• Michel, Anna
• Gremeaux, Vincent
• Muff, Guillaume
• Pache, Basile
• Larcinese, Ana
• Benaim, Charles
• Geinoz, Sandrine
• Martin, David
• Besson, Cyril
• Kayser, Bengt
• Demartines, Nicolas
• Hübner, Martin

Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Prehabilitation may improve postoperative clinical outcomes among patients undergoing major abdominal surgery. This study evaluated the potential effects of a high-intensity interval training (HIIT) program performed before major abdominal surgery on patients’ cardiorespiratory fitness and functional ability (secondary outcomes of pilot trial NCT02953119).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Patients were included before surgery to engage in a low-volume HIIT program with 3 sessions per week for 3 weeks. Cardiopulmonary exercise and 6-min walk (6MWT) testing were performed pre- and post-prehabilitation.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Fourteen patients completed an average of 8.6 ± 2.2 (mean ± SD) sessions during a period of 27.9 ± 6.1 days. After the program,<jats:inline-formula><jats:alternatives><jats:tex-math>{{V}}</jats:tex-math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover><mml:mi>V</mml:mi><mml:mo>˙</mml:mo></mml:mover></mml:math></jats:alternatives></jats:inline-formula>O<jats:sub>2</jats:sub> peak (+ 2.4 ml min<jats:sup>−1</jats:sup> kg<jats:sup>−1</jats:sup>, 95% CI 0.8–3.9, <jats:italic>p</jats:italic> = 0.006), maximal aerobic power (+ 16.8 W, 95% CI 8.2–25.3, <jats:italic>p</jats:italic> = 0.001), <jats:inline-formula><jats:alternatives><jats:tex-math>{{V}}</jats:tex-math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mover><mml:mi>V</mml:mi><mml:mo>˙</mml:mo></mml:mover></mml:math></jats:alternatives></jats:inline-formula>O<jats:sub>2</jats:sub> at anaerobic threshold (+ 1.2 ml min<jats:sup>−1</jats:sup> kg<jats:sup>−1</jats:sup>, 95%CI 0.4–2.1, <jats:italic>p</jats:italic> = 0.009) and power at anaerobic threshold (+ 12.4 W, 95%CI 4.8–20, <jats:italic>p</jats:italic> = 0.004) were improved. These changes were not accompanied by improved functional capacity (6MWT: + 2.6 m, 95% CI (− 19.6) to 24.8, <jats:italic>p</jats:italic> = 0.800).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>A short low-volume HIIT program increases cardiorespiratory fitness but not walking capacity in patients scheduled for major abdominal surgery. These results need to be confirmed by larger studies.</jats:p></jats:sec>

Topics

• size-exclusion chromatography
• chemical ionisation