| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Faid, Amna H.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2024Reducing the effective dose of cisplatin using cobalt modified silver nano-hybrid as a carriers on MCF7 and HCT cell modelscitations
- 2024Laser photostability of chitosan coated gold-GO nanocomposite and its role as a nano-therapeutic agent for control breast cancer growthcitations
- 2024Antitumor efficiency and photostability of newly green synthesized silver/graphene oxide nanocomposite on different cancer cell linescitations
- 2024Laser enhanced photothermal effect of silver nanoparticles synthesized by chemical and green method on Gram-positive and Gram-negative bacteriacitations
- 2023Laser Enhanced Combinatorial Chemo-photothermal Therapy of Green Synthesis Gold Nanoparticles Loaded with 6Mercaptopurine on Breast Cancer Modelcitations
- 2022Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer modelcitations
Places of action
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article
Enhanced cytotoxic effect of doxorubicin conjugated gold nanoparticles on breast cancer model
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>The difficulty of achieving targeted drug delivery following administration of presently marketed anticancer therapeutics is still a concern. Metallic nanoparticles (NPs) appear to be promising in this regard. The present study focused on the use of gold nanoparticles (AuNPs) as a drug carrier for anticancer Doxorubicin (DOX) forming DOX–AuNPs nanocomposite. The anticancer effect of the prepared nanocomposite was evaluated using SRP essay on breast cancer cell line (MCF7) for different incubation times (24 h,48, and72hr). The prepared DOX–AuNPs nanocomposite was investigated by UV–visible spectroscopy, TEM, fluorescence spectroscopy, and FTIR spectroscopy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Our results showed that the prepared AuNPs and DOX–AuNPs nanocomposite have spherical and small size10 ± 2 nm and 12 ± 2 nm respectively. The potential cytotoxicity of the DOX-AuNPs nanocomposite on the MCF7 cell line was significantly increased compared to free DOX. The 20 µM DOX- AuNPs nanocomposite produced a similar decrease in cell survival as 80 µM free DOX.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Future work is in progress to investigate the positive effects of the prepared nanocomposite for chemo-photothermal combination treatment.</jats:p></jats:sec>