Materials Map

Discover the materials research landscape. Find experts, partners, networks.

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (2/2 displayed)

  • 2022Spatial Distribution of <i>Plasmodium falciparum</i> and <i>Plasmodium vivax</i> in Northern Ethiopia by Microscopic, Rapid Diagnostic Test, Laboratory Antibody, and Antigen Data5citations
  • 2018Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Ethiopia17citations

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Chart of shared publication
Solomon, Hiwot
2 / 2 shared
Murphy, Matt
1 / 1 shared
Assefa, Ashenafi
2 / 3 shared
Drakeley, Chris
1 / 2 shared
Sime, Heven
2 / 2 shared
Kebede, Amha
2 / 2 shared
Mohammed, Hussein
1 / 2 shared
Rogier, Eric
1 / 2 shared
Ali, Ahmed
1 / 3 shared
Malone, Joseph
1 / 1 shared
Shi, Ya Ping
1 / 1 shared
Zhou, Zhiyong
1 / 1 shared
Abebe, Getachew
1 / 1 shared
Tsegaye, Wendimagegn
1 / 1 shared
Deressa, Wakgari
1 / 2 shared
Teka, Hiwot
1 / 1 shared
Abreha, Tesfay
1 / 1 shared
Kassa, Moges
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Jima, Daddi
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2022
2018

Co-Authors (by relevance)

  • Solomon, Hiwot
  • Murphy, Matt
  • Assefa, Ashenafi
  • Drakeley, Chris
  • Sime, Heven
  • Kebede, Amha
  • Mohammed, Hussein
  • Rogier, Eric
  • Ali, Ahmed
  • Malone, Joseph
  • Shi, Ya Ping
  • Zhou, Zhiyong
  • Abebe, Getachew
  • Tsegaye, Wendimagegn
  • Deressa, Wakgari
  • Teka, Hiwot
  • Abreha, Tesfay
  • Kassa, Moges
  • Jima, Daddi
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article

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in Ethiopia

  • Ali, Ahmed
  • Hwang, Jimee
  • Solomon, Hiwot
  • Assefa, Ashenafi
  • Malone, Joseph
  • Shi, Ya Ping
  • Zhou, Zhiyong
  • Sime, Heven
  • Abebe, Getachew
  • Tsegaye, Wendimagegn
  • Deressa, Wakgari
  • Teka, Hiwot
  • Abreha, Tesfay
  • Kassa, Moges
  • Jima, Daddi
  • Kebede, Amha
Abstract

<p>BACKGROUND: Building on the declining trend of malaria in Ethiopia, the Federal Ministry of Health aims to eliminate malaria by 2030. As Plasmodium falciparum and Plasmodium vivax are co-endemic in Ethiopia, the use of primaquine is indicated for both transmission interruption and radical cure, respectively. However, the limited knowledge of the local prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency and its associated variants has hindered the use of primaquine.</p><p>METHODS: Some 11,138 dried blood spot (DBS) samples were collected in 2011 as part of a national, household Malaria Indicator Survey, a multi-stage nationally representative survey of all malaria-endemic areas of Ethiopia. A randomly selected sub-set of 1414 DBS samples was successfully genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Considering the geographical position and ethnic mix of the country, three common variants: G6PD*A (A376G), G6PD*A- (G202A) and Mediterranean (C563T) were investigated.</p><p>RESULTS: Of the 1998 randomly selected individuals, 1429 (71.5%) DBS samples were genotyped and merged to the database, of which 53.5% were from females. G6PD*A (A376G) was the only genotype detected. No sample was positive for either G6PD*A- (G202A) or Mediterranean (C563T) variants. The prevalence of G6PD*A (A376G) was 8.9% [95% confidence interval (CI) 6.7-11.2] ranging from 12.2% in the Southern Nations, Nationalities and Peoples' (95% CI 5.7-18.7) to none in Dire Dawa/Harari Region.</p><p>CONCLUSION: The common G6PD*A- (G202A) or Mediterranean (C563T) variants were not observed in this nationwide study. The observed G6PD*A (A376G) mutation has little or no clinical significance. These findings supported the adoption of primaquine for P. falciparum transmission interruption and radical cure of P. vivax in Ethiopia. As the presence of other clinically important, less common variants cannot be ruled out, the implementation of radical cure will be accompanied by active haematological and adverse events monitoring in Ethiopia.</p>

Topics
  • impedance spectroscopy
  • laser emission spectroscopy
  • chemical ionisation