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| Motta, Antonella |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Petrov, R. H. | Madrid |
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| Azam, Siraj |
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| Ali, M. A. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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Joniau, Inge
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article
Spiroplasma infection as a cause of severe congenital keratouveitis, cataract and glaucoma
Abstract
<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Only seven cases of ocular <jats:italic>Spiroplasma</jats:italic> infection have been reported to date, all presenting as congenital cataracts with concomitant intraocular inflammation. We describe the first case of <jats:italic>Spiroplasma</jats:italic> infection initially presenting as a corneal infiltrate.</jats:p></jats:sec><jats:sec><jats:title>Case presentation</jats:title><jats:p>A 1-month-old girl was referred for a corneal infiltrate in the left eye. She presented in our hospital with unilateral keratouveitis. Examination showed a stromal corneal infiltrate and dense white keratic precipitates in the left eye. Herpetic keratouveitis was suspected and intravenous acyclovir therapy was initiated. Two weeks later, the inflammation in the left eye persisted and was also noticed in the right eye. Acute angle-closure glaucoma and a cataract with dilated iris vessels extending onto the anterior lens capsule developed in the left eye. The inflammation resolved after treatment with azithromycin. Iridectomy, synechiolysis and lensectomy were performed. Bacterial metagenomic sequencing (<jats:italic>16 S rRNA</jats:italic>) and transmission electron microscopy revealed <jats:italic>Spiroplasma ixodetis</jats:italic> species in lens aspirates and biopsy. Consequently, a diagnosis of bilateral <jats:italic>Spiroplasma</jats:italic> uveitis was made.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In cases of congenital cataract with concomitant intraocular inflammation, <jats:italic>Spiroplasma</jats:italic> infection should be considered. The purpose of this case report is to raise awareness of congenital <jats:italic>Spiroplasma</jats:italic> infection as a cause of severe keratouveitis, cataract and angle-closure glaucoma in newborns. Performing molecular testing on lens aspirates is essential to confirm diagnosis. Systemic macrolides are suggested as the mainstay of treatment.</jats:p></jats:sec>