Materials Map

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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

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Publications (45/45 displayed)

  • 2021Influence of Twin Boundaries and Sample Dimensions on the Mechanical Behavior of Ag Nanowirescitations
  • 2020Oil-in-water separation with graphene-based nanocomposite membranes for produced water treatment177citations
  • 2020Patterned, morphing composites via maskless photo-click lithography3citations
  • 2020Nanoindentation of Molecular Crystals: Lessons Learned from Aspirin38citations
  • 2020Direct 3D Printing of Graphene Using Capillary Suspensions33citations
  • 2020Size Effects on Strength and Plasticity of Ferrite and Austenite Pillars in a Duplex Stainless Steelcitations
  • 2020Tiled Monolayer Films of 2D Molybdenum Disulphide Nanoflakes Assembled at Liquid/Liquid Interfaces29citations
  • 2019The size dependent strength of Fe, Nb and V micropillars at room and low temperature25citations
  • 2017Solution Processing of Two-Dimensional Black Phosphorus67citations
  • 2017Graphene-reinforced chitosan/PDMS morphing compositescitations
  • 2017Stabilization of a T -ZrO2 polymorph in a glassy SiO2 matrix at elevated temperatures accomplished by ceria additions26citations
  • 2017Tetragonal to cubic transformation of SiO2 stabilized ZrO2 polymorph through dysprosium substitutions26citations
  • 2016Frequency-modulated atomic force microscopy localises viscoelastic remodelling in the ageing sheep aorta17citations
  • 2016A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsies18citations
  • 2015Biomechanical Changes of Collagen Cross-Linking on Human Keratoconic Corneas Using Scanning Acoustic Microscopy.10citations
  • 2015Mechanical properties of porous ceramic scaffolds: Influence of internal dimensions201citations
  • 2015Mechanical properties of porous ceramic scaffolds: Influence of internal dimensions:Influence of Internal Dimensions201citations
  • 2014Biomechanical changes after repeated collagen cross-linking on human corneas assessed in vitro using scanning acoustic microscopy25citations
  • 2014Combining AFM and Acoustic Probes to Reveal Changes in the Elastic Stiffness Tensor of Living Cells44citations
  • 2014Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs137citations
  • 2014Localized micro- and nano-scale remodelling in the diabetic aorta23citations
  • 2013Biomechanical properties of human corneas following low- and high-intensity collagen cross-linking determined with scanning acoustic microscopy51citations
  • 2013Scanning acoustic microscopy for mapping the microelastic properties of human corneal tissue28citations
  • 2012Multi-layer phase analysis: Quantifying the elastic properties of soft tissues and live cells with ultra-high-frequency scanning acoustic microscopy25citations
  • 2012Gel-cast glass-ceramic tissue scaffolds of controlled architecture produced via stereolithography of moulds27citations
  • 2011The mechanical properties of float glass surfaces measured by nanoindentation and acoustic microscopy26citations
  • 2011Quantifying micro-mechanical properties of soft biological tissues with scanning acoustic microscopy7citations
  • 2009Limits to feature size and resolution in ink jet printing161citations
  • 2008Residual stress distributions around indentations and scratches in polycrystalline Al2O3 and Al2O3/SiC nanocomposites measured using fluorescence probes37citations
  • 2008Nanoindentation of histological specimens using an extension of the Oliver and Pharr method4citations
  • 2007Correlations for single-crystal elastic constants of compound semiconductors and their representation in isomechanical groups23citations
  • 2007Characterization of photo-reduced silver organometallic salt deposited by inkjet printingcitations
  • 2005Viscosity and acoustic behavior of ceramic suspensions optimized for phase-change ink-jet printing48citations
  • 2004Modelling of R-curve behaviour in ceramic-metal laminates3citations
  • 2004Thermal stress induced microcracking in alumina-20% SiCp composites53citations
  • 2004In Situ Characterization of Interfaces between Liquid Tin-Vanadium Alloys and Alumina by Neutron Reflection Spectroscopy9citations
  • 2003Characterisation of void and reinforcement distributions in a metal matrix composite by X-ray edge-contrast microtomography13citations
  • 2003Multilayer nitride coatings by closed field unbalanced magnetron sputter ion plating21citations
  • 2002Direct ink jet printing of alumina componentscitations
  • 2001Residual stress and subsurface damage in machined alumina and alumina/silicon carbide nanocomposite ceramics67citations
  • 2001Accurate determination of Young's modulus and Poisson's ratio of thin films by a combination of acoustic microscopy and nanoindentation64citations
  • 2001Detection of particle damage event by acoustic emission during tensile straining of SiC particle reinforced aluminum alloy compositescitations
  • 2001Direct Ink Jet Printing of Alumina Components1citations
  • 2000Matrix flow and densification during the consolidation of matrix coated fibres26citations
  • 2000Freeform Fabrication of Ceramics by Hot-Melt Ink-Jet Printing13citations

Places of action

Chart of shared publication
Yilmaz, Halil
3 / 3 shared
Eggeman, Alexander
1 / 7 shared
Williams, Craig
2 / 5 shared
Zhao, Hu
1 / 1 shared
Alammar, Abdulaziz
1 / 4 shared
Williams, Craig J.
3 / 4 shared
Park, Sang-Hee
1 / 2 shared
Aguilar-Tadeo, Julio Adrian
2 / 2 shared
Gresil, Matthieu
1 / 31 shared
Lyu, Shida
2 / 3 shared
Kinloch, Ian A.
1 / 59 shared
Soutis, Costas
2 / 356 shared
Wu, Rui
1 / 7 shared
Blaker, Jonny J.
1 / 15 shared
Lin, Fei
1 / 4 shared
Zheng, Fei
2 / 3 shared
Cruz-Cabeza, Aurora J.
1 / 5 shared
Gabriele, Benjamin P. A.
1 / 2 shared
Lauer, Matthias Eckhard
1 / 1 shared
Barg, Suelen
1 / 17 shared
Ding, Hui
1 / 6 shared
Neilson, Joseph
1 / 2 shared
Avery, Michael P.
1 / 3 shared
Risan, Jared
1 / 1 shared
Haigh, Sj
1 / 63 shared
Brent, John
1 / 3 shared
Lewis, Dj
1 / 30 shared
Lewis, Edward
1 / 4 shared
Blaker, Jonny
1 / 9 shared
Vasanthavel, S.
1 / 1 shared
Kannan, S.
1 / 42 shared
Kanaan, Sanjeevi
1 / 1 shared
Vasanthavel, Subramaniyan
1 / 1 shared
Sherratt, Michael J.
6 / 7 shared
Akhtar, R.
2 / 5 shared
Trafford, Andrew
1 / 1 shared
Chadwick, R.
1 / 1 shared
Gavara, N.
1 / 1 shared
Graham, Helen
1 / 1 shared
Akhtar, Riaz
8 / 14 shared
Cruickshank, J. Kennedy
1 / 2 shared
Weber, Thomas
1 / 5 shared
Zhao, Xuegen
7 / 7 shared
Carley, Fiona
4 / 4 shared
Brahma, Arun
4 / 4 shared
Radhakrishnan, Hema
4 / 4 shared
Hillarby, Chantal
1 / 1 shared
Odonnell, Clare
4 / 4 shared
Beshtawi, Ithar M.
4 / 4 shared
Gough, Julie
3 / 7 shared
Sabree, Israa
2 / 2 shared
Hillarby, M. Chantal
3 / 3 shared
Ballestrem, Christoph
2 / 2 shared
Zhao, X.
2 / 27 shared
Carisey, A.
1 / 1 shared
Nijenhuis, N.
1 / 1 shared
Mcconnell, James C.
1 / 1 shared
Clarke, Louise E.
1 / 1 shared
Richardson, Stephen M.
1 / 6 shared
Hoyland, Judith A.
1 / 6 shared
Cruickshank, J. K.
1 / 1 shared
Gardiner, Natalie
1 / 1 shared
Barrett, S. D.
1 / 1 shared
Graham, H. K.
1 / 1 shared
Walton, L. A.
1 / 1 shared
Nijenhuis, Nadja
1 / 1 shared
Wilkinson, Steven J.
1 / 1 shared
Murphy, Lilli
1 / 1 shared
Watson, Rachel E. B.
3 / 3 shared
Chopra, K.
1 / 1 shared
Mummery, Pm
2 / 20 shared
Goodman, Oriel
1 / 1 shared
Wilkinson, Steven
1 / 2 shared
Stringer, J.
1 / 5 shared
Roberts, S. G.
2 / 8 shared
Wu, H. Z.
1 / 1 shared
Schwarzer, Norbert
1 / 1 shared
Bierwisch, Nick
1 / 1 shared
Bojun, Xu
1 / 1 shared
Stringer, Jonathan
1 / 6 shared
Reis, Nuno
1 / 5 shared
Ainsley, Christopher
1 / 1 shared
El-Shaer, Y.
1 / 1 shared
Todd, R. I.
1 / 5 shared
Holt, Stephen
1 / 1 shared
Webster, John R. P.
1 / 5 shared
Winn, Andrew J.
1 / 1 shared
Anderson, Paul
1 / 9 shared
Justice, Ian
1 / 1 shared
Elliott, James
1 / 5 shared
Davis, Graham
1 / 1 shared
Inkson, B. J.
1 / 4 shared
Cooke, K. E.
2 / 3 shared
Bamber, M.
1 / 1 shared
Boscarino, D.
1 / 2 shared
Rigato, V.
1 / 3 shared
Teer, D. G.
1 / 7 shared
Steer, T.
1 / 1 shared
Figueras, A.
1 / 2 shared
Bassas, J.
1 / 1 shared
Ainsley, C.
1 / 1 shared
Reis, N.
1 / 2 shared
Wu, H.
1 / 23 shared
Bamber, M. J.
1 / 1 shared
Mann, A. B.
1 / 2 shared
Aoyagi, Naritoshi
1 / 1 shared
Reis, Nuno
2 / 2 shared
Ainsley, Chris
1 / 1 shared
Ward-Close, C.
1 / 1 shared
Schüler, S.
1 / 1 shared
Wood, M.
1 / 2 shared
Seerden, K. A. M.
1 / 1 shared
Grant, Patrick
1 / 4 shared
Evans, Jrg
1 / 2 shared
Chart of publication period
2021
2020
2019
2017
2016
2015
2014
2013
2012
2011
2009
2008
2007
2005
2004
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2002
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Co-Authors (by relevance)

  • Yilmaz, Halil
  • Eggeman, Alexander
  • Williams, Craig
  • Zhao, Hu
  • Alammar, Abdulaziz
  • Williams, Craig J.
  • Park, Sang-Hee
  • Aguilar-Tadeo, Julio Adrian
  • Gresil, Matthieu
  • Lyu, Shida
  • Kinloch, Ian A.
  • Soutis, Costas
  • Wu, Rui
  • Blaker, Jonny J.
  • Lin, Fei
  • Zheng, Fei
  • Cruz-Cabeza, Aurora J.
  • Gabriele, Benjamin P. A.
  • Lauer, Matthias Eckhard
  • Barg, Suelen
  • Ding, Hui
  • Neilson, Joseph
  • Avery, Michael P.
  • Risan, Jared
  • Haigh, Sj
  • Brent, John
  • Lewis, Dj
  • Lewis, Edward
  • Blaker, Jonny
  • Vasanthavel, S.
  • Kannan, S.
  • Kanaan, Sanjeevi
  • Vasanthavel, Subramaniyan
  • Sherratt, Michael J.
  • Akhtar, R.
  • Trafford, Andrew
  • Chadwick, R.
  • Gavara, N.
  • Graham, Helen
  • Akhtar, Riaz
  • Cruickshank, J. Kennedy
  • Weber, Thomas
  • Zhao, Xuegen
  • Carley, Fiona
  • Brahma, Arun
  • Radhakrishnan, Hema
  • Hillarby, Chantal
  • Odonnell, Clare
  • Beshtawi, Ithar M.
  • Gough, Julie
  • Sabree, Israa
  • Hillarby, M. Chantal
  • Ballestrem, Christoph
  • Zhao, X.
  • Carisey, A.
  • Nijenhuis, N.
  • Mcconnell, James C.
  • Clarke, Louise E.
  • Richardson, Stephen M.
  • Hoyland, Judith A.
  • Cruickshank, J. K.
  • Gardiner, Natalie
  • Barrett, S. D.
  • Graham, H. K.
  • Walton, L. A.
  • Nijenhuis, Nadja
  • Wilkinson, Steven J.
  • Murphy, Lilli
  • Watson, Rachel E. B.
  • Chopra, K.
  • Mummery, Pm
  • Goodman, Oriel
  • Wilkinson, Steven
  • Stringer, J.
  • Roberts, S. G.
  • Wu, H. Z.
  • Schwarzer, Norbert
  • Bierwisch, Nick
  • Bojun, Xu
  • Stringer, Jonathan
  • Reis, Nuno
  • Ainsley, Christopher
  • El-Shaer, Y.
  • Todd, R. I.
  • Holt, Stephen
  • Webster, John R. P.
  • Winn, Andrew J.
  • Anderson, Paul
  • Justice, Ian
  • Elliott, James
  • Davis, Graham
  • Inkson, B. J.
  • Cooke, K. E.
  • Bamber, M.
  • Boscarino, D.
  • Rigato, V.
  • Teer, D. G.
  • Steer, T.
  • Figueras, A.
  • Bassas, J.
  • Ainsley, C.
  • Reis, N.
  • Wu, H.
  • Bamber, M. J.
  • Mann, A. B.
  • Aoyagi, Naritoshi
  • Reis, Nuno
  • Ainsley, Chris
  • Ward-Close, C.
  • Schüler, S.
  • Wood, M.
  • Seerden, K. A. M.
  • Grant, Patrick
  • Evans, Jrg
OrganizationsLocationPeople

article

Growth differentiation factor 6 and transforming growth factor-beta differentially mediate mesenchymal stem cell differentiation, composition, and micromechanical properties of nucleus pulposus constructs

  • Mcconnell, James C.
  • Clarke, Louise E.
  • Richardson, Stephen M.
  • Sherratt, Michael J.
  • Hoyland, Judith A.
  • Derby, Brian
Abstract

Introduction: Currently, there is huge research focus on the development of novel cell-based regeneration and tissue-engineering therapies for the treatment of intervertebral disc degeneration and the associated back pain. Both bone marrow-derived (BM) mesenchymal stem cells (MSCs) and adipose-derived MSCs (AD-MSCs) are proposed as suitable cells for such therapies. However, currently no consensus exists as to the optimum growth factor needed to drive differentiation to a nucleus pulposus (NP)-like phenotype. The aim of this study was to investigate the effect of growth differentiation factor-6 (GDF6), compared with other transforming growth factor (TGF) superfamily members, on discogenic differentiation of MSCs, the matrix composition, and micromechanics of engineered NP tissue constructs.Methods: Patient-matched human AD-MSCs and BM-MSCs were seeded into type I collagen hydrogels and cultured in differentiating media supplemented with TGF-β3, GDF5, or GDF6. After 14 days, quantitative polymerase chain reaction analysis of chondrogenic and novel NP marker genes and sulfated glycosaminoglycan (sGAG) content of the construct and media components were measured. Additionally, construct micromechanics were analyzed by using scanning acoustic microscopy (SAM).Results: GDF6 stimulation of BM-MSCs and AD-MSCs resulted in a significant increase in expression of novel NP marker genes, a higher aggrecan-to-type II collagen gene expression ratio, and higher sGAG production compared with TGF-β or GDF5 stimulation. These effects were greater in AD-MSCs than in BM-MSCs. Furthermore, the acoustic-wave speed measured by using SAM, and therefore tissue stiffness, was lowest in GDF6-stiumlated AD-MSC constructs.Conclusions: The data suggest that GDF6 stimulation of AD-MSCs induces differentiation to an NP-like phenotype and results in a more proteoglycan-rich matrix. Micromechanical analysis shows that the GDF6-treated AD-MSCs have a less-stiff matrix composition, suggesting that the growth factor is inducing a matrix that is more akin to the native NP-like tissue. Thus, this cell and growth-factor combination may be the ideal choice for cell-based intervertebral disc (IVD)-regeneration therapies. © 2014 Clarke et al.; licensee BioMed Central Ltd.

Topics
  • impedance spectroscopy
  • laser emission spectroscopy
  • scanning auger microscopy