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The Materials Map is an open tool for improving networking and interdisciplinary exchange within materials research. It enables cross-database search for cooperation and network partners and discovering of the research landscape.

The dashboard provides detailed information about the selected scientist, e.g. publications. The dashboard can be filtered and shows the relationship to co-authors in different diagrams. In addition, a link is provided to find contact information.

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The Materials Map is still under development. In its current state, it is only based on one single data source and, thus, incomplete and contains duplicates. We are working on incorporating new open data sources like ORCID to improve the quality and the timeliness of our data. We will update Materials Map as soon as possible and kindly ask for your patience.

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in Cooperation with on an Cooperation-Score of 37%

Topics

Publications (1/1 displayed)

  • 2010A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults14citations

Places of action

Chart of shared publication
Price, Ric N.
1 / 1 shared
Engwerda, Christian R.
1 / 1 shared
Amante, Fiona H.
1 / 1 shared
Lampah, Daniel A.
1 / 1 shared
Haque, Ashraful
1 / 2 shared
Montgomery, Grant W.
1 / 1 shared
Mcsweeney, Karli M.
1 / 1 shared
Anstey, Nicholas M.
1 / 1 shared
Le, Lien
1 / 1 shared
Salwati, Ervi
1 / 1 shared
Granger, Donald L.
1 / 1 shared
Stanley, Amanda C.
1 / 1 shared
Woodberry, Tonia
1 / 1 shared
Zhou, Yonghong
1 / 1 shared
Zhao, Zhen Z.
1 / 1 shared
Rivera, Fabian De Labastida
1 / 1 shared
Handojo, Tjandra
1 / 1 shared
Weinberg, J. Brice
1 / 1 shared
Piera, Kim A.
1 / 1 shared
Tjitra, Emiliana
1 / 1 shared
Mwaikambo, Esther D.
1 / 1 shared
Kenangalem, Enny
1 / 2 shared
Chart of publication period
2010

Co-Authors (by relevance)

  • Price, Ric N.
  • Engwerda, Christian R.
  • Amante, Fiona H.
  • Lampah, Daniel A.
  • Haque, Ashraful
  • Montgomery, Grant W.
  • Mcsweeney, Karli M.
  • Anstey, Nicholas M.
  • Le, Lien
  • Salwati, Ervi
  • Granger, Donald L.
  • Stanley, Amanda C.
  • Woodberry, Tonia
  • Zhou, Yonghong
  • Zhao, Zhen Z.
  • Rivera, Fabian De Labastida
  • Handojo, Tjandra
  • Weinberg, J. Brice
  • Piera, Kim A.
  • Tjitra, Emiliana
  • Mwaikambo, Esther D.
  • Kenangalem, Enny
OrganizationsLocationPeople

article

A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults

  • Hobbs, Maurine R.
  • Price, Ric N.
  • Engwerda, Christian R.
  • Amante, Fiona H.
  • Lampah, Daniel A.
  • Haque, Ashraful
  • Montgomery, Grant W.
  • Mcsweeney, Karli M.
  • Anstey, Nicholas M.
  • Le, Lien
  • Salwati, Ervi
  • Granger, Donald L.
  • Stanley, Amanda C.
  • Woodberry, Tonia
  • Zhou, Yonghong
  • Zhao, Zhen Z.
  • Rivera, Fabian De Labastida
  • Handojo, Tjandra
  • Weinberg, J. Brice
  • Piera, Kim A.
  • Tjitra, Emiliana
  • Mwaikambo, Esther D.
  • Kenangalem, Enny
Abstract

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Severe malaria (SM) syndromes caused by <jats:italic>Plasmodium falciparum</jats:italic> infection result in major morbidity and mortality each year. However, only a fraction of <jats:italic>P. falciparum</jats:italic> infections develop into SM, implicating host genetic factors as important determinants of disease outcome. Previous studies indicate that tumour necrosis factor (TNF) and lymphotoxin alpha (LTα) may be important for the development of cerebral malaria (CM) and other SM syndromes.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>An extensive analysis was conducted of single nucleotide polymorphisms (SNPs) in the <jats:italic>TNF, LTA</jats:italic> and <jats:italic>LTB</jats:italic> genes in highland Papuan children and adults, a population historically unexposed to malaria that has migrated to a malaria endemic region. Generated <jats:italic>P</jats:italic>-values for SNPs spanning the <jats:italic>LTA/TNF/LTB</jats:italic> locus were corrected for multiple testing of all the SNPs and haplotype blocks within the region tested through 10,000 permutations. A global P-value of &lt; 0.05 was considered statistically significant.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No associations between SNPs in the <jats:italic>TNF/LTA/LTB</jats:italic> locus and susceptibility to SM in highland Papuan children and adults were found.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These results support the notion that unique selective pressure on the <jats:italic>TNF/LTA/LTB</jats:italic> locus in different populations has influenced the contribution of the gene products from this region to SM susceptibility.</jats:p></jats:sec>

Topics
  • size-exclusion chromatography
  • susceptibility