| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Blunn, Gw
University of Portsmouth
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defectscitations
- 2022Design and in vivo testing of novel single-stage tendon graft using polyurethane nanocomposite polymer for tendon reconstructioncitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implantscitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implants.
- 2017Clinical cold welding of the modular total hip arthroplasty prosthesiscitations
- 2017Intrinsic osteoinductivity of porous titanium scaffold for bone tissue engineeringcitations
- 2017Fretting corrosion behavior of nitinol spinal rods in conjunction with titanium pedicle screwscitations
- 2016Corrosion at the head-neck interface of current designs of modular femoral componentscitations
- 2016Metal concentrations in the blood and tissues after implantation of titanium growth guidance sliding instrumentationcitations
- 2016Nanohydroxyapatite effect on the degradation, osteoconduction and mechanical properties of polymeric bone tissue engineered scaffoldscitations
- 2015The effect of frictional torque and bending moment on corrosion at the taper interfacecitations
- 2015Lessons from retrievalscitations
- 2015Analysis of retrieved growth guidance sliding LSZ-4D devices for early onset scoliosis and investigation of the use of nitinol rods for this systemcitations
- 2015Silicate-substituted calcium phosphate with enhanced strut porosity stimulates osteogenic differentiation of human mesenchymal stem cellscitations
- 2014Low dose of propranolol does not affect rat osteotomy healing and callus strengthcitations
- 2013Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topographycitations
- 2011Enhancing the soft tissue seal around intraosseous transcutaneous amputation prostheses using silanized fibronectin titanium alloycitations
- 2008Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.citations
- 2006Porous Ti-6Al-4V bone replacement materials produced by Selective Laser Sintering (SLS)
- 2004The effect of diamond like carbon and hydroxyapatite coatings on soft tissue reactions to external fixation screws under load
- 2000Fractographic examination of racing greyhound central (navicular) tarsal bone failure surfaces using scanning electron microscopy
Places of action
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article
Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.
Abstract
<p><b>Purpose</b>: To report the use of a composite ceramic bone graft substitute containing calcium sulphate and hydroxyapatite (HA) in the treatment of large expansive osteolytic benign bone tumours. <br/></p><p><b>Methods</b>: 4 women and 9 men aged 8 to 49 (mean, 22) years with aneurysmal bone cysts (n=6) or giant cell tumours (n=7) in the epi- or meta-physeal areas of the lower limbs underwent curettage, phenolisation, and filling with bone graft substitute containing calcium sulphate and HA. The mean tumour size was 38.5 (range, 18-65) ml. The patients were followed up for a mean of 41 (range, 33-52) months. Range of movement, Musculoskeletal Tumor Society Rating Score (MTSRS), and haematological and blood biochemical parameters were measured. <br/></p><p><b>Results</b>: Two patients had recurrence at 7 and 9 months, both progressed to grade-III giant cell tumours. One underwent revision with an iliac crest autograft, whereas the other underwent en bloc excision and prosthetic replacement. The 11 other lesions displayed clinical and radiological consolidation at a mean of 4.6 (range, 3-7) months. No restriction of range of movement was observed, except in the patient undergoing prosthetic replacement. The mean MTSRS was 96% (range, 83-100%) of that expected for normal function. During the follow-up period, haematological and blood biochemical parameters stayed within normal limits. <br/></p><p><b>Conclusion</b>: Composite bioceramic osteoconductive grafts, which combine porous HA with calcium sulphate, provide a framework for human osteogenesis and avoid donor-site morbidity (autologous bone graft harvesting). Tumour recurrence remains a major concern especially in young patients, as revision invariably requires removal of additional bone, potentially compromising joint integrity.</p>