| People | Locations | Statistics |
|---|---|---|
| Naji, M. |
| |
| Motta, Antonella |
| |
| Aletan, Dirar |
| |
| Mohamed, Tarek |
| |
| Ertürk, Emre |
| |
| Taccardi, Nicola |
| |
| Kononenko, Denys |
| |
| Petrov, R. H. | Madrid |
|
| Alshaaer, Mazen | Brussels |
|
| Bih, L. |
| |
| Casati, R. |
| |
| Muller, Hermance |
| |
| Kočí, Jan | Prague |
|
| Šuljagić, Marija |
| |
| Kalteremidou, Kalliopi-Artemi | Brussels |
|
| Azam, Siraj |
| |
| Ospanova, Alyiya |
| |
| Blanpain, Bart |
| |
| Ali, M. A. |
| |
| Popa, V. |
| |
| Rančić, M. |
| |
| Ollier, Nadège |
| |
| Azevedo, Nuno Monteiro |
| |
| Landes, Michael |
| |
| Rignanese, Gian-Marco |
|
Knowles, Jonathan C.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (33/33 displayed)
- 2024Titanium-doped phosphate glasses containing zinc and strontium applied in bone regeneration
- 2024A sol-gel templating route for the synthesis of hierarchical porous calcium phosphate glasses containing zinccitations
- 20243D Melt-Extrusion Printing of Medium Chain Length Polyhydroxyalkanoates and Their Application as Antibiotic-Free Antibacterial Scaffolds for Bone Regenerationcitations
- 2023Biodegradable and Sustainable Synthetic Antibodies—A Perspective
- 2021Antibacterial Composite Materials Based on the Combination of Polyhydroxyalkanoates With Selenium and Strontium Co-substituted Hydroxyapatite for Bone Regenerationcitations
- 2020Modulation of neuronal cell affinity of composite scaffolds based on polyhydroxyalkanoates and bioactive glassescitations
- 2018Binary polyhydroxyalkanoate systems for soft tissue engineeringcitations
- 2016Composite scaffolds for cartilage tissue engineering based on natural polymers of bacterial origin, thermoplastic poly(3‐hydroxybutyrate) and micro‐fibrillated bacterial cellulosecitations
- 2016P(3HB) Based Magnetic Nanocomposites: Smart Materials for Bone Tissue Engineeringcitations
- 2015Novel sol–gel preparation of (P2O5)0.4–(CaO)0.25–(Na2O)X–(TiO2)(0.35−X) bioresorbable glasses (X = 0.05, 0.1, and 0.15)citations
- 2015Titanium phosphate glass microcarriers induce enhanced osteogenic cell proliferation and human mesenchymal stem cell protein expressioncitations
- 2013Aspirin-loaded P(3HO)/P(3HB) blend films: potential materials for biodegradable drug-eluting stentscitations
- 2012Novel Biodegradable and Biocompatible Poly(3‐hydroxyoctanoate)/Bacterial Cellulose Compositescitations
- 2012Structural characterization of titanium-doped Bioglass using isotopic substitution neutron diffractioncitations
- 2012Structural characterization and physical properties of P2O5-CaO-Na2O-TiO2 glasses by Fourier transform infrared, Raman and solid-state magic angle spinning nuclear magnetic resonance spectroscopies.citations
- 2012Titanium phosphate glass microspheres for bone tissue engineering.citations
- 2010Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Fillercitations
- 2010Poly(3-hydroxybutyrate) multifunctional composite scaffolds for tissue engineering applications.citations
- 2010<i>In vitro</i> studies on the influence of surface modification of Ni–Ti alloy on human bone cellscitations
- 2010Reactive calcium-phosphate-containing poly(ester-co-ether) methacrylate bone adhesives: chemical, mechanical and biological considerations.citations
- 2009A study of the formation of amorphous calcium phosphate and hydroxyapatite on melt quenched Bioglass(A (R)) using surface sensitive shallow angle X-ray diffractioncitations
- 2009Structure and properties of strontium-doped phosphate-based glassescitations
- 2009Incorporation of vitamin E in poly(3hydroxybutyrate)/Bioglass composite films: effect on surface properties and cell attachment.citations
- 2009Doping of a high calcium oxide metaphosphate glass with titanium dioxidecitations
- 2008Structural characteristics of antibacterial bioresorbable phosphate glasscitations
- 2008A high-energy X-ray diffraction, P-31 and B-11 solid-state NMR study of the structure of aged sodium borophosphate glassescitations
- 2008An X-ray absorption spectroscopy study of the local environment of iron in degradable iron-phosphate glassescitations
- 2008Comparison of nanoscale and microscale bioactive glass on the properties of P(3HB)/Bioglass composites.citations
- 2007The structure and properties of silver-doped phosphate-based glassescitations
- 2007The structure of phosphate glass biomaterials from neutron diffraction and 31P nuclear magnetic resonance datacitations
- 2006Initial responses of human osteoblasts to sol-gel modified titanium with hydroxyapatite and titania composition.citations
- 2006X-ray absorption spectroscopy and high-energy XRD study of the local environment of copper in antibacterial copper-releasing degradable phosphate glassescitations
- 2006Initial responses of human osteoblasts to sol–gel modified titanium with hydroxyapatite and titania composition
Places of action
| Organizations | Location | People |
|---|
article
Titanium phosphate glass microcarriers induce enhanced osteogenic cell proliferation and human mesenchymal stem cell protein expression
Abstract
<jats:p> In this study, we have developed 50- to 100-µm-sized titanium phosphate glass microcarriers (denoted as Ti5) that show enhanced proliferation of human mesenchymal stem cells and MG63 osteosarcoma cells, as well as enhanced human mesenchymal stem cell expression of bone differentiation markers, in comparison with commercially available glass microspheres at all time points. We also demonstrate that these microcarriers provide superior human mesenchymal stem cell proliferation with conventional Dulbecco’s Modified Eagle medium than with a specially developed commercial stem cell medium. The microcarrier proliferative capacity is revealed by a 24-fold increase in MG63 cell numbers in spinner flask bioreactor studies performed over a 7-day period, versus only a 6-fold increase in control microspheres under the same conditions; the corresponding values of Ti5 and control microspheres under static culture are 8-fold and 7-fold, respectively. The capability of guided osteogenic differentiation is confirmed by ELISAs for bone morphogenetic protein-2 and osteopontin, which reveal significantly greater expression of these markers, especially osteopontin, by human mesenchymal stem cells on the Ti5 microspheres than on the control. Scanning electron microscopy and confocal laser scanning microscopy images reveal favorable MG63 and human mesenchymal stem cell adhesion on the Ti5 microsphere surfaces. Thus, the results demonstrate the suitability of the developed microspheres for use as microcarriers in bone tissue engineering applications. </jats:p>