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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Petrov, R. H. | Madrid |
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| Azam, Siraj |
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| Azevedo, Nuno Monteiro |
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Carlota, Rivera Gladys
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article
Endovascular treatment simulations using a novel <i>in vitro</i> brain arteriovenous malformation model based on three-dimensional printing millifluidic technology
Abstract
<jats:sec><jats:title>Background</jats:title><jats:p> Brain arteriovenous malformations (bAVM) are complex vascular diseases. Several models have been used to simulate endovascular treatments; thus in vitro models have not been widely employed because it has been difficult to recreate realistic phantoms of this disease. </jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p> To describe the development and evaluate the preliminary experience of a novel bAVM in vitro model for endovascular embolization using millifluidic three-dimensional (3D) printing technology. </jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p> We designed a bAVM phantom starting from simple to more complex designs, composed of a nidus, feeding arteries and draining vein. We recreate the design by using millifluidic technology with stereolithography 3D printing. Structural and functional tests were performed using angiographic images and computer flow dynamics. Treatment simulations with ethylene vinyl alcohol were tested using two different microcatheter position techniques. A Likert-scale questionnaire was applied to perform a qualitative evaluation of the model. </jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p> We developed a realistic model of a bAVM with hollow channels. The structural evaluation showed a high precision of the 3D printing process. Embolization tests with the liquid agent gave similar sensations and material behaviour as in vivo cases. There were no significant differences between microcatheter position techniques, thus we observed a trend for better nidus filling with a deeper in-nidus position technique. </jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p> We were able to create and test a novel bAVM in vitro model with stereolithography 3D printing in resin. It showed a high capacity for simulating endovascular embolization characteristics, with an excellent user experience. It could be potentially used for training and testing of bAVM embolizations. </jats:p></jats:sec>