| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Damia, Chantal
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2022Laser powder bed fusion of ultra-high-molecular-weight polyethylene/hydroxyapatite composites for bone tissue engineeringcitations
- 2021Chemical Functionalization of Calcium Phosphate Bioceramic Surfacescitations
- 2019Pre-osteoblast cell colonization of porous silicon substituted hydroxyapatite bioceramics: Influence of microporosity and macropore designcitations
- 2019Functionalization of Hydroxyapatite Ceramics: Raman Mapping Investigation of Silanizationcitations
- 2019Functionalization of Hydroxyapatite Ceramics: Raman Mapping Investigation of Silanizationcitations
- 2017Functionalisation of silicon substituted hydroxyapatite bioceramics by BMP-2 for bone tissue engineering
- 2016Hydroxyapatite microporous bioceramics as vancomycin reservoir: Antibacterial efficiency and biocompatibility investigationcitations
- 2016Quantitative analysis of vascular colonisation and angio-conduction in porous silicon-substituted hydroxyapatite with various pore shapes in a chick chorioallantoic membrane (CAM) modelcitations
- 2015Elaboration of osteoinductive phosphocalcic bioceramics for bone tissue engineering
- 2014In vitro and in vivo evaluation of silicated hydroxyapatite and impact of insulin adsorptioncitations
- 2011Processing, physico-chemical characterisation and in vitro evaluation of silicon containing β-tricalcium phosphate ceramicscitations
- 2010Surface transformation of silicon-doped hydroxyapatite immersed in culture medium under dynamic and static conditionscitations
Places of action
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article
Hydroxyapatite microporous bioceramics as vancomycin reservoir: Antibacterial efficiency and biocompatibility investigation
Abstract
Infections after bone reconstructive surgery are a real therapeutic and economic issue for the modern health care system. As the pathogen (most often Staphylococcus aureus) is able to develop a biofilm inside the bone, local delivery of antibiotics is of interest since high drug concentrations would be delivered directly at the target place. In this context, this study evaluated a porous hydroxyapatite implant as biocompatible bone substitute and vancomycin-delivery system to prevent post-operative infections. A simple method of impregnation with optimised conditions insured a high antibiotic loading (up to 2.3 AE 0.3 mg/m 2), with a complete in vitro release obtained within 1–5 days. Additionally, the bacteriostatic and bactericidal effects of vancomycin were retained after loading on hydroxyapatite, as demonstrated after challenge with a Staphylococcus aureus strain. Regarding the biocompatibility, a wound healing assay of pre-osteoblastic MC3T3-E1 cells exposed to various concentrations of vancomycin revealed a dose-dependent reduction in cell migration for antibiotic concentrations higher than 1 mg/mL. Meanwhile, cells were able to proliferate normally on vancomycin-loaded scaffolds, although cell initial adhesion was seriously impaired for scaffolds loaded with 2.3 mg/m 2. Loaded scaffolds could be stored up to three months at room temperature without any degradation of the antibiotic. Together, these results demonstrate the efficacy of these hydroxyapatite bone substitutes for local delivery of vanco-mycin in the context of bone infection.