| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Magnaudeix, Amandine
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (11/11 displayed)
- 2024Ultra-High Frequency Dielectrophoresis to Characterize Mesenchymal Stem Cells Differentiation: Application to bioceramics synthesis
- 2022Processing by Laser Stereolithography and In Vitro Biological Evaluation of Hydroxyapatite Scaffolds Mimicking Human Trabecular Bone Architecture
- 2022Processing by Laser Stereolithography and <i>In Vitro</i> Biological Evaluation of Hydroxyapatite Scaffolds Mimicking Human Trabecular Bone Architecture
- 2022Laser powder bed fusion of ultra-high-molecular-weight polyethylene/hydroxyapatite composites for bone tissue engineeringcitations
- 2022Calcium phosphate bioceramics: From cell behavior to chemical-physical propertiescitations
- 2022New Approach to Identify the Physiological State of Bone Cells at the Surface of Hydroxyapatite Bioceramicscitations
- 2021Sintering and biocompatibility of copper-doped hydroxyapatite bioceramicscitations
- 2021Chemical Functionalization of Calcium Phosphate Bioceramic Surfacescitations
- 2019Pre-osteoblast cell colonization of porous silicon substituted hydroxyapatite bioceramics: Influence of microporosity and macropore designcitations
- 2016Hydroxyapatite microporous bioceramics as vancomycin reservoir: Antibacterial efficiency and biocompatibility investigationcitations
- 2016Quantitative analysis of vascular colonisation and angio-conduction in porous silicon-substituted hydroxyapatite with various pore shapes in a chick chorioallantoic membrane (CAM) modelcitations
Places of action
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article
Hydroxyapatite microporous bioceramics as vancomycin reservoir: Antibacterial efficiency and biocompatibility investigation
Abstract
Infections after bone reconstructive surgery are a real therapeutic and economic issue for the modern health care system. As the pathogen (most often Staphylococcus aureus) is able to develop a biofilm inside the bone, local delivery of antibiotics is of interest since high drug concentrations would be delivered directly at the target place. In this context, this study evaluated a porous hydroxyapatite implant as biocompatible bone substitute and vancomycin-delivery system to prevent post-operative infections. A simple method of impregnation with optimised conditions insured a high antibiotic loading (up to 2.3 AE 0.3 mg/m 2), with a complete in vitro release obtained within 1–5 days. Additionally, the bacteriostatic and bactericidal effects of vancomycin were retained after loading on hydroxyapatite, as demonstrated after challenge with a Staphylococcus aureus strain. Regarding the biocompatibility, a wound healing assay of pre-osteoblastic MC3T3-E1 cells exposed to various concentrations of vancomycin revealed a dose-dependent reduction in cell migration for antibiotic concentrations higher than 1 mg/mL. Meanwhile, cells were able to proliferate normally on vancomycin-loaded scaffolds, although cell initial adhesion was seriously impaired for scaffolds loaded with 2.3 mg/m 2. Loaded scaffolds could be stored up to three months at room temperature without any degradation of the antibiotic. Together, these results demonstrate the efficacy of these hydroxyapatite bone substitutes for local delivery of vanco-mycin in the context of bone infection.