| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Fawzy, Amr
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2024Effect of inositol hexaphosphate acid versus polyacrylic acid on dentin properties and adhesion of a self-adhesive restorative material to dentincitations
- 2024The Synergistic Effect of High Intensity Focused Ultrasound on In-vitro Remineralization of Tooth Enamel by Calcium Phosphate Ion Clusterscitations
- 2024Flowable resin-based composites modified with chlorhexidine-loaded mesoporous silica nanoparticles induce superior antibiofilm properties
- 2022Cytotoxicity and antimicrobial efficiency of ZrO2 nanoparticles reinforced 3D printed resinscitations
- 2022Development of 3D printed dental resin nanocomposite with graphene nanoplatelets enhanced mechanical properties and induced drug-free antimicrobial activity.citations
- 2021Development of 3D printed resin reinforced with modified ZrO2 nanoparticles for long-term provisional dental restorationscitations
- 2021Formulation of pH-sensitive chlorhexidine-loaded/mesoporous silica nanoparticles modified experimental dentin adhesivecitations
- 2020The Effect of Cross-linking Efficiency of Drug-Loaded Novel Freeze Gelated Chitosan Templates for Periodontal Tissue Regenerationcitations
- 2020Effect of acid etching on dentin bond strength of ultra-mild self-etch adhesivescitations
- 2020Properties of a modified quaternary ammonium silane formulation as a potential root canal irrigant in endodonticscitations
- 2020In vitro bonding performance of modern self-adhesive resin cements and conventional resin-modified glass ionomer cements to prosthetic substratescitations
- 2019Resin-based dental composites for tooth filling
- 2019Macrophage response and surface analysis of dental cementum after treatment with high intensity focused ultrasoundcitations
- 2019An in vitro study of a novel quaternary ammonium silane endodontic irrigantcitations
- 2019Co-blend application mode of bulk fill composite resincitations
- 2018In vitro assessment of ribose modified two-step etch-and-rinse dentine adhesivecitations
- 2017Proanthocyanidins-Loaded Nanoparticles Enhance Dentin Degradation Resistancecitations
- 2017Potentiating the antibacterial effect of silver nanospheres by surface-capping with chlorhexidine gluconatecitations
- 2015Characterization of antibacterial and adhesion properties of chitosan-modified glass ionomer cementcitations
- 2012Riboflavin as a dentin crosslinking agentcitations
- 2009Effect acidic and alkaline/heat treatments on the bond strength of different luting cements to commercially pure titaniumcitations
- 2009Tensile bond strength of immediately repaired anterior microfine hybrid restorative composite using nontrimmed hourglass specimens
- 2008Effect of surface treatments on the tensile bond strength of repaired water-aged anterior restorative micro-fine hybrid resin compositecitations
Places of action
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article
Proanthocyanidins-Loaded Nanoparticles Enhance Dentin Degradation Resistance
Abstract
<p>Previous studies reported that grapeseed extract (GSE), which is rich in proanthocyanidins (PAs), improves the biodegradation resistance of demineralized dentin. This study aimed to investigate the effect of a new GSE delivery strategy to demineralized dentin through loading into biodegradable polymer poly-[lactic-co-glycolic acid] (PLGA) nanoparticles on the biodegradation resistance in terms of structural stability and surface/bulk mechanical and biochemical properties with storage time in collagenase-containing solutions. GSE-loaded nanoparticles were synthetized by nanoprecipitation at PLGA/GSE (w/w) ratios of 100:75, 100:50, and 100:25 and characterized for their morphological/structural features, physicochemical characteristics, and drug loading, entrapment, and release. Nanoparticle suspensions in distilled water (12.5% w/v) were applied (1 min) to demineralized dentin specimens by simulating pulpal pressure. The nanoparticle delivery was investigated by scanning electron microscopy (SEM)/transmission electron microscopy (TEM), and the GSE release from the delivered nanoparticles was further characterized. The variations in surface and bulk mechanical properties were characterized in terms of reduced elastic-modulus, hardness, nanoindentation testing, and apparent elastic-modulus with a storage time up to 3 mo. Hydroxyproline release with exposure to collagenase up to 7 d was estimated. An etch-and-rinse dentin adhesive was applied to investigate the morphology of the resin-dentin interface after nanoparticle delivery. Treatment with the GSE-loaded nanoparticles enhanced the collagen fibril structural resistance, reflected from the TEM investigation, and improved the biomechanical and biochemical stability of demineralized dentin. Nanoparticles having PLGA/GSE of 100:75 (w/w) showed the highest cumulative GSE release and were associated with the best improvement in biodegradation resistance. TEM/SEM showed the ability of the nanoparticles to infiltrate dentinal tubules' main and lateral branches. SEM revealed the formation of a uniform hybrid layer and well-formed resin tags with the presence of numerous nanoparticles located within the dentinal tubules and/or attached to the resin tag. This study demonstrated the potential significance of delivering collagen crosslinkers loaded into biodegradable polymer nanoparticles through the dentinal tubules of demineralized dentin on the biodegradation resistance.</p>