| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Akhtar, Riaz
University of Liverpool
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (14/14 displayed)
- 2022Ligament mechanics of ageing and osteoarthritic human kneescitations
- 2018Facile production of nanocomposites of carbon nanotubes and polycaprolactone with high aspect ratios with potential applications in drug deliverycitations
- 2017Dual-stimuli responsive injectable microgel/solid drug nanoparticle nanocomposites for release of poorly soluble drugscitations
- 2016A pilot study of scanning acoustic microscopy as a tool for measuring arterial stiffness in aortic biopsiescitations
- 2015Using intermolecular interactions to crosslink PIM- 1 and modify its gas sorption properties
- 2015Using intermolecular interactions to crosslink PIM-1 and modify its gas sorption propertiescitations
- 2015Biomechanical Changes of Collagen Cross-Linking on Human Keratoconic Corneas Using Scanning Acoustic Microscopy.citations
- 2014Biomechanical changes after repeated collagen cross-linking on human corneas assessed in vitro using scanning acoustic microscopycitations
- 2013Biomechanical properties of human corneas following low- and high-intensity collagen cross-linking determined with scanning acoustic microscopycitations
- 2013Scanning acoustic microscopy for mapping the microelastic properties of human corneal tissuecitations
- 2012Multi-layer phase analysis: Quantifying the elastic properties of soft tissues and live cells with ultra-high-frequency scanning acoustic microscopycitations
- 2011Quantifying micro-mechanical properties of soft biological tissues with scanning acoustic microscopycitations
- 2008Mapping the Micromechanical Properties of Cryo-sectioned Aortic Tissue with Scanning Acoustic Microscopycitations
- 2008Nanoindentation of histological specimens using an extension of the Oliver and Pharr methodcitations
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article
Biomechanical changes after repeated collagen cross-linking on human corneas assessed in vitro using scanning acoustic microscopy
Abstract
PURPOSE. To explore the biomechanical changes induced by repeated cross-linking using scanning acoustic microscopy (SAM). METHODS. Thirty human corneas were divided into three groups. In group A, five corneas were cross-linked once. In group B, five corneas were cross-linked twice, 24 hours apart. In group C, five corneas were cross-linked three times, 24 hours apart. The contralateral controls in all groups had similar treatment but without UV-A. The speed of sound, which is directly proportional to the square root of the tissue's elastic modulus, was assessed using SAM. RESULTS. In group A, the speed of sound of the treated corneas was 1677.38 ± 10.70 ms-1 anteriorly and 1603.90 ± 9.82 ms-1 posteriorly, while it was 1595.23 ± 9.66 ms-1 anteriorly and 1577.13 ± 8.16 ms-1 posteriorly in the controls. In group B, the speed of sound of the treated corneas was 1746.33 ± 23.37 ms-1 anteriorly and 1631.60 ± 18.92 ms-1 posteriorly, while it was 1637.57 ± 22.15 ms-1 anteriorly and 1612.30 ± 22.23 ms-1 posteriorly in the controls. In group C, the speed of sound of the treated corneas was 1717.97 ± 18.92 ms-1 anteriorly and 1616.62 ± 17.58 ms-1 posteriorly, while it was 1628.69 ± 9.37 ms-1 anteriorly and 1597.68 ± 11.97 ms-1 posteriorly in the controls. The speed of sound in the anterior (200 × 200 μm) region between the cross-linked and control corneas in groups A, B, and C was increased by a factor of 1.051 (P = 0.005), 1.066 (P = 0.010), and 1.055 (P = 0.005) respectively. However, there was no significant difference among the cross-linked corneas in all groups (P = 0.067). CONCLUSIONS. A significant increase in speed of sound was found in all treated groups compared with the control group; however, the difference among the treated groups is not significant, suggesting no further cross-links are induced when collagen cross-linking treatment is repeated.