| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Ye, Shu
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2016A blood pressure-associated variant of the SLC39A8 gene influences cellular cadmium accumulation and toxicitycitations
- 2010Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFκBcitations
- 2009Myopia and polmorphisms in genes for matrix metalloproteinasescitations
- 2003Variation in the matrix metalloproteinase-1 gene and risk of coronary heart diseasecitations
- 2003Haplotypic analysis of the MMP-9 gene in relation to coronary artery diseasecitations
Places of action
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article
Myopia and polmorphisms in genes for matrix metalloproteinases
Abstract
PURPOSE. To investigate the relation between myopia and variations in three genes coding for matrix metalloproteinases, enzymes that degrade matrix proteins and modulate scleral extensibility. <br/>METHODS. Three hundred sixty-six men and women, from Sheffield, United Kingdom, were genotyped for the 1G/2G polymorphism in the MMP-1 gene, the 5A/6A polymorphism in the MMP-3 gene and the ArgGln polymorphism in exon 6 of the MMP-9 gene and assessed for refractive error. <br/>RESULTS. Risk of myopia was increased in people homozygous for the 5A allele of the MMP-3 gene (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.1–9.0) compared to those who were homozygous for the 6A allele, and in people homozygous for the Gln allele in exon 6 of the MMP-9 gene (OR, 2.8; 95% CI, 1.1–7.0) compared to those who were homozygous for the Arg allele. People who were homozygous for the 2G allele of the MMP-1 gene had an odds ratio for myopia of 2.3 (95% CI, 0.9–6.1), compared with those who were homozygous for the 1G allele, although this relation did not reach statistical significance. Risk of myopia increased progressively with the dose of these three alleles, showing a greater than 10-fold difference across the range.