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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Chinnaswamy, Mahendran
in Cooperation with on an Cooperation-Score of 37%
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Publications (2/2 displayed)
- 2020La<sup>3+</sup>/Sr<sup>2+</sup> Dual-Substituted Hydroxyapatite Nanoparticles as Bone Substitutes: Synthesis, Characterization, <i>In Vitro</i> Bioactivity and Cytocompatibilitycitations
- 2020Effect of anions on the structural, morphological and dielectric properties of hydrothermally synthesized hydroxyapatite nanoparticlescitations
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article
La<sup>3+</sup>/Sr<sup>2+</sup> Dual-Substituted Hydroxyapatite Nanoparticles as Bone Substitutes: Synthesis, Characterization, <i>In Vitro</i> Bioactivity and Cytocompatibility
Abstract
<jats:p>The present study aims to synthesize biocompatible and bioactive lanthanum (La<jats:sup>3+</jats:sup>)/strontium (Sr<jats:sup>2+</jats:sup>) dual ion doped hydroxyapatite (HA) nanomaterials by sol–gel method. The discrete substitution of La<jats:sup>3+</jats:sup> and Sr<jats:sup>2+</jats:sup> in pure HA enhances theosteoconductivity. The co-substitution of various La<jats:sup>3+</jats:sup> concentrations (0.03, 0.06 and 0.1 M) regulates the physical and <jats:italic>In Vitro</jats:italic> properties. The study also investigates the effect of La<jats:sup>3+</jats:sup>/Sr<jats:sup>2+</jats:sup> substituents on the crystalline property, microstructure,photoluminescence and <jats:italic>In Vitro</jats:italic> bioactivity of HA samples. La<jats:sup>3+</jats:sup>/Sr<jats:sup>2+</jats:sup> co-substitution decreases the crystallite size of HA without any significant distortion of the crystal structure. In addition, the dual ions doping influences nanoparticles morphology by reducingthe particle size from 75 to 20 nm. The <jats:italic>In Vitro</jats:italic> bioactivity tests for the La<jats:sup>3+</jats:sup>/Sr<jats:sup>2+</jats:sup> co-substituted HA confirm the osteoconductive boneapatite generating capacity. Bactericidal tests against <jats:italic>Staphylococcus aureus</jats:italic> and <jats:italic>Pseudomonas aeruginosa</jats:italic> stainsshow better resistivity of La<jats:sup>3+</jats:sup>/Sr<jats:sup>2+</jats:sup>-HA samples. To authenticate the biocompatibility and antimicrobial activity of the synthesized La<jats:sup>3+</jats:sup>/Sr<jats:sup>2+</jats:sup> dual doped HA nanoparticles for bone implant applications, different tests like cell viability and toxicitywere conducted using human lung A549 cells.</jats:p>