| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Urquhart, Andrew J.
Technical University of Denmark
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (12/12 displayed)
- 2022Reactive Oxygen Species-Responsive Polymer Nanoparticles to Improve the Treatment of Inflammatory Skin Diseasescitations
- 2019Pressure-induced polymorphism of caprolactam: A neutron diffraction studycitations
- 2017Compression of glycolide-h4 to 6GPacitations
- 2017Compression of glycolide-h 4 to 6GPacitations
- 2015Polymorphism of a polymer precursor: metastable glycolide polymorph recovered via large scale high-pressure experimentscitations
- 2012Polymer templating of supercooled indomethacin for polymorph selectioncitations
- 2012Inclusion of water insoluble drugs in amorphous silica nanoparticlescitations
- 2011ToF-SIMS Analysis of Dexamethasone Distribution in the Isolated Perfused Eyecitations
- 2011Polymorphism and polymerisation of acrylic and methacrylic acid at high pressurecitations
- 2011ToF-SIMS analysis of ocular tissues reveals biochemical differentiation and drug distributioncitations
- 2009Partial least squares regression as a powerful tool for investigating large combinatorial polymer librariescitations
- 2008TOF-SIMS analysis of a 576 micropatterned copolymer array to reveal surface moieties that control wettabilitycitations
Places of action
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article
Inclusion of water insoluble drugs in amorphous silica nanoparticles
Abstract
<p>Amorphous silica nanoparticles (a-SiNPs) with high surface area and small pore size have been synthesized using a zwitterionic surfactant in acid media. The produced nanoparticles displayed large specific surface area (∼850 m<sup>2</sup>/g) with an average particles size of 45 nm. The loading efficiency was assessed by incorporating three model water insoluble active substances Carbamazepine (CBZ), Ibuprofen (IBU) and Cyclosporin (CyA) via passive loading and it was found to varying from 15-40%. The loaded silica nanoparticles were analyzed using X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC) to investigate the state of the adsorbed active agents. CyA was found to be in amorphous state, IBU was partially crystalline while CBZ was transformed into form I. The dissolution profiles showed rapid release for CBZ while IBU and CyA demonstrated prolonged release for 24 hr. The viability of Caco-2 cells was not affected in the presence of a-SiNPs showing negligible cytotoxicity (85%) at high concentrations up to 15 mg/ml. Copyright © 2012 American Scientific Publishers All rights reserved.</p>