| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Colliot, Olivier
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (3/3 displayed)
- 2020The White Matter Module-Hub Network of Semantics Revealed by Semantic Dementiacitations
- 2019Predicting progression to Alzheimer’s disease from clinical and imaging data: a reproducible study
- 2018Early cognitive, structural and microstructural changes in c9orf72 presymptomatic carriers before 40 years of agecitations
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article
The White Matter Module-Hub Network of Semantics Revealed by Semantic Dementia
Abstract
2AbstractCognitive neuroscience exploring the architecture of semantics has shown that coherent supra-modalconceptsarecomputedintheanteriortemporallobes(ATL)butitisunknown how/where modularinformation implemented by posterior cortices (word/object/face forms) is conveyed to the ATL hub. We investigated the semantic module-hub network in healthy adults (N=19)andinsemanticdementiapatients(N= 28)bycombiningsemanticassessmentsof verbal and non-verbal stimuli and MRI-based fiber tracking usingseeds in three module-related corticesimplementingi)writtenwordforms(‘VisualWordFormArea’),ii)abstractlexical representations(posterior-superiortemporalcortices),andiii)face/objectrepresentations (‘Face Form Area’).Fiber tracking revealed three key tracts linking the ATL with the three module-related cortices. Correlation analyses between tract parameters and semantic scores indicated that the three tracts subservesemantics,transferringmodularverbalornon-verbalobject/faceinformation tothe leftandrightATL,respectively.Themodule-hubtractswerefunctionallyandmicro-structurally damaged in semantic dementia whereas damage to non-module specific ATL tracts (inferiorlongitudinalfasciculus,uncinatefasciculus)hadmorelimitedimpactonsemantic failure.Thesefindingsidentifymajorcomponentsofthewhitemattermodule-hubnetworkof semanticsandtheycorroborate/materializeclaimsofcognitivemodelspositingdirectlinks betweenmodularandsemanticrepresentations. Incombinationwithmodularaccountsof cognition, they also suggest that the currently prevailing ‘hub-and-spokes’ model of semantics couldbeextendedbyincorporatinganintermediatemodulelevelcontaininginvariant representations,inadditionto‘spokes’whichsubservetheprocessingofanear-unlimited number of sensori-motor and speech-sound features.