| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Kumar, Sandeep
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2025Multifunctional characterization of high tensile strength PEO/PVP blend based composites with InAs nanowire fillers for structural sodium ion batteries
- 2024Meta-Learning for Real-World Class Incremental Learning: A Transformer-Based Approach
- 2023Influence of single nucleotide polymorphism in the <i>IGF-1</i> gene on performance and conformation traits in Munjal sheepcitations
- 2023Artificial synaptic characteristics of PVA:ZnO nanocomposite memristive devicescitations
- 2023Simultaneous realization of FIR-based multimode optical thermometry and photonic molecular logic gates in Er<sup>3+</sup> and Yb<sup>3+</sup> co-doped SrTiO<sub>3</sub> phosphorcitations
- 2022Feasibility Analysis of Machining Cobalt-Chromium Alloy (Stellite-6) Using TiN Coated Binary Insertscitations
- 2022Mathematical Expressions Model to forecast for Chloride Ion Penetration and Comp. Strength of Recycled Coarse Aggregate Concrete Incorporating Meta-kaolincitations
- 2022Strength Evaluation of Functionalized MWCNT-Reinforced Polymer Nanocomposites Synthesized Using a 3D Mixing Approachcitations
- 2022High performance computing for modelling of stereolithography process
- 2021A nanostructured cellulose-based interphase layer to enhance the mechanical performance of glass fibre-reinforced polymer compositescitations
- 2021Topological phonons in an inhomogeneously strained silicon-2: Evidence of spin-momentum locking
- 2021Topological phonons in an inhomogeneously strained silicon-4: Large spin dependent thermoelectric response and thermal spin transfer torque due to topological electronic magnetism of phonons
- 2020Investigation on the influence of multi-step processing on the mechanical and thermal properties of cellulose reinforced EVOH compositescitations
- 2020High performance multiscale glass fibre epoxy composites integrated with cellulose nanocrystals for advanced structural applicationscitations
- 2020Flexoelectric effect mediated spin-to-charge conversion at amorphous-Si thin film interfaces
- 20201D semiconductor nanowires for energy conversion, harvesting and storage applicationscitations
- 20201D semiconductor nanowires for energy conversion, harvesting and storage applicationscitations
- 2018Recent Advances in Discotic Liquid Crystal-Assisted Nanoparticlescitations
- 2017High electrochemical performance flexible solid-state supercapacitor based on Co-doped reduced graphene oxide and silk fibroin composites.citations
- 2017Carboxybetaine-modified succinylated chitosan-based beads encourage pancreaticβ-cells (Min-6) to form islet-like spheroids under in vitro conditionscitations
- 2017Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1citations
- 2015Influence of processing conditions on properties of poly (vinyl acetate)/ cellulose nanocrystals nanocomposites
- 2014Thermal properties and eutectic behaviour of dapivirine in combination with steroid hormones and other antiretrovirals
Places of action
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article
Disturbed Flow Promotes Arterial Stiffening Through Thrombospondin-1
Abstract
<jats:sec><jats:title>Background:</jats:title><jats:p>Arterial stiffness and wall shear stress are powerful determinants of cardiovascular health, and arterial stiffness is associated with increased cardiovascular mortality. Low and oscillatory wall shear stress, termed disturbed flow (d-flow), promotes atherosclerotic arterial remodeling, but the relationship between d-flow and arterial stiffness is not well understood. The objective of this study was to define the role of d-flow on arterial stiffening and discover the relevant signaling pathways by which d-flow stiffens arteries.</jats:p></jats:sec><jats:sec><jats:title>Methods:</jats:title><jats:p>D-flow was induced in the carotid arteries of young and old mice of both sexes. Arterial stiffness was quantified ex vivo with cylindrical biaxial mechanical testing and in vivo from duplex ultrasound and compared with unmanipulated carotid arteries from 80-week-old mice. Gene expression and pathway analysis was performed on endothelial cell–enriched RNA and validated by immunohistochemistry. In vitro testing of signaling pathways was performed under oscillatory and laminar wall shear stress conditions. Human arteries from regions of d-flow and stable flow were tested ex vivo to validate critical results from the animal model.</jats:p></jats:sec><jats:sec><jats:title>Results:</jats:title><jats:p>D-flow induced arterial stiffening through collagen deposition after partial carotid ligation, and the degree of stiffening was similar to that of unmanipulated carotid arteries from 80-week-old mice. Intimal gene pathway analyses identified transforming growth factor-β pathways as having a prominent role in this stiffened arterial response, but this was attributable to thrombospondin-1 (TSP-1) stimulation of profibrotic genes and not changes to transforming growth factor-β. In vitro and in vivo testing under d-flow conditions identified a possible role for TSP-1 activation of transforming growth factor-β in the upregulation of these genes. TSP-1 knockout animals had significantly less arterial stiffening in response to d-flow than wild-type carotid arteries. Human arteries exposed to d-flow had similar increases TSP-1 and collagen gene expression as seen in our model.</jats:p></jats:sec><jats:sec><jats:title>Conclusions:</jats:title><jats:p>TSP-1 has a critical role in shear-mediated arterial stiffening that is mediated in part through TSP-1’s activation of the profibrotic signaling pathways of transforming growth factor-β. Molecular targets in this pathway may lead to novel therapies to limit arterial stiffening and the progression of disease in arteries exposed to d-flow.</jats:p></jats:sec>