| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Wang, Lei
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (23/23 displayed)
- 2023An analysis of rotationally moulded sandwich structure’s repeated impact properties
- 2023Fusion of Ni Plating on CP-Titanium by Electron Beam Single-Track Scanning: Toward a New Approach for Fabricating TiNi Self-Healing Shape Memory Coating
- 2022Green synthesis of Ag/Fe3O4 nanoparticles using Mentha longifolia flower extract: evaluation of its antioxidant and anti-lung cancer effects
- 2022An atomistic simulation study of rapid solidification kinetics and crystal defects in dilute Al–Cu alloyscitations
- 2022Multiscale analysis of crystalline defect formation in rapid solidification of pure aluminium and aluminium–copper alloyscitations
- 2022Reprocessed materials used in rotationally moulded sandwich structures for enhancing environmental sustainability: low-velocity impact and flexure-after-impact responsescitations
- 2022Multiscale analysis of crystal defect formation in rapid solidification of pure aluminium and aluminium-copper alloys
- 2022Mechanically Flexible Thermoelectric Hybrid Thin Films by Introduction of PEDOT:PSS in Nanoporous Ca3Co4O9citations
- 2021On the use of limestone calcined clay cement (LC<sup>3</sup>) in high-strength strain-hardening cement-based composites (HS-SHCC)citations
- 2021Bimetallic effects on Zn-Cu electrocatalysts enhance activity and selectivity for the conversion of CO2 to COcitations
- 2021Growth and optical properties of CaxCoO2 thin filmscitations
- 2021Guiding the Catalytic Properties of Copper for Electrochemical CO2 Reduction by Metal Atom Decoration.citations
- 2020The role of zinc in metakaolin-based geopolymerscitations
- 2020Unconventional valley-dependent optical selection rules and landau level mixing in bilayer graphenecitations
- 2019Magic continuum in twisted bilayer WSe2
- 2019An investigation of low velocity impact properties of rotationally molded skin–foam–skin sandwich structurecitations
- 2018Fracture toughness of rotationally molded polyethylene and polypropylenecitations
- 2016Nonlinear Generation of Vector Beams from AlGaAs Nanoantennascitations
- 2016Electron optics with p-n junctions in ballistic graphenecitations
- 2014Charge Control And Wettability Alteration At Solid-liquid Interfacescitations
- 2011A Common Genetic Variant in the 3′-UTR of Vacuolar H <sup>+</sup> -ATPase <i>ATP6V0A1</i> Creates a Micro-RNA Motif to Alter Chromogranin A Processing and Hypertension Riskcitations
- 2008Heritability and Genome-Wide Linkage in US and Australian Twins Identify Novel Genomic Regions Controlling Chromogranin Acitations
- 2007Polysulfide networks. in Situ formation and characterization of the elastomeric behaviorcitations
Places of action
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article
Heritability and Genome-Wide Linkage in US and Australian Twins Identify Novel Genomic Regions Controlling Chromogranin A
Abstract
<jats:p><jats:bold><jats:italic>Background—</jats:italic></jats:bold>Chromogranin A (CHGA) triggers catecholamine secretory granule biogenesis, and its catestatin fragment inhibits catecholamine release. We approached catestatin heritability using twin pairs, coupled with genome-wide linkage, in a series of twin and sibling pairs from 2 continents.</jats:p><jats:p><jats:bold><jats:italic>Methods and Results—</jats:italic></jats:bold>Hypertensive patients had elevated CHGA coupled with reduction in catestatin, suggesting diminished conversion of precursor to catestatin. Heritability for catestatin in twins was 44% to 60%. Six hundred fifteen nuclear families yielded 870 sib pairs for linkage, with significant logarithm of odds peaks on chromosomes 4p, 4q, and 17q. Because acidification of catecholamine secretory vesicles determines CHGA trafficking and processing to catestatin, we genotyped at positional candidate<jats:italic>ATP6N1</jats:italic>, bracketed by peak linkage markers on chromosome 17q, encoding a subunit of vesicular H<jats:sup>+</jats:sup>-translocating ATPase. The minor allele diminished CHGA secretion and processing to catestatin. The<jats:italic>ATP6N1</jats:italic>variant also influenced blood pressure in 1178 individuals with the most extreme blood pressure values in the population. In chromaffin cells, inhibition of H<jats:sup>+</jats:sup>-ATPase diverted CHGA from regulated to constitutive secretory pathways.</jats:p><jats:p><jats:bold><jats:italic>Conclusions—</jats:italic></jats:bold>We established heritability of catestatin in twins from 2 continents. Linkage identified 3 regions contributing to catestatin, likely novel determinants of sympathochromaffin exocytosis. At 1 such positional candidate (<jats:italic>ATP6N1</jats:italic>), variation influenced CHGA secretion and processing to catestatin, confirming the mechanism of a novel<jats:italic>trans</jats:italic>-QTL for sympathochromaffin activity and blood pressure.</jats:p>