• Hakeem, Abbassaeed
• Khalid, Hina
• Farooq, Imran
• Alakrawi, Kawthermoosa
• Saadi, Omarwaqas

Abstract

<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To compare the in vitro potential of dentin tubule occlusion of two novel experimental dentifrices consisting of fluoride containing bioactive glass (BG) with zinc oxide nanoparticles. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;/i&gt;&lt;/b&gt; Forty-eight dentin discs (&lt;i&gt;n&lt;/i&gt; = 48) were divided into 6 groups (&lt;i&gt;n&lt;/i&gt; = 8), based on their brushing dentifrices: Group 1 = artificial saliva (AS; control); Group 2 = fluoride dentifrice (Colgate Palmolive&lt;sup&gt;©&lt;/sup&gt;, UK); Group 3 = experimental nonactive agent dentifrice; Group 4 = experimental dentifrice with 1.5% BG; Group 5 = experimental dentifrice with 4% BG; and Group 6 = BioMinF&lt;sup&gt;©&lt;/sup&gt; dentifrice. Postbrushing, the discs were subjected to acidic challenge with 6% wt citric acid (pH = 4.0) for 1 min. Scanning electron microscope (SEM) and energy-dispersive X-ray (EDX) spectroscopy were performed pre- and post-citric acid challenges, and percentages of tubule occlusion assessed. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; SEM micrographs of group 1 (AS) show no tubule occlusion (0%), whereas those of groups 2 and 3 show partial tubule occlusion (25 to &amp;#x3c;50% of tubules occluded). The SEM micrographs of dentifrices containing fluoride-BG (groups 4, 5, and 6) show that most of the tubules (&amp;#x3e;50 and &amp;#x3c;100%) were occluded. For all the groups (excluding group 1), pre- and post-citric acid challenge values are statistically significant (&lt;i&gt;p&lt;/i&gt; &amp;#x3c; 0.05). EDX analysis reveals the presence of zinc in experimental dentifrices only. &lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; The results of novel experimental dentifrices are comparable to those of the BioMinF&lt;sup&gt;©&lt;/sup&gt;, in terms of tubule occlusion. Dentifrices containing BG could serve as an alternative in dentin sensitivity management.</jats:p>

Topics

• nanoparticle
• scanning electron microscopy
• zinc
• glass
• glass
• Energy-dispersive X-ray spectroscopy