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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Rebelo, A.
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (17/17 displayed)
- 2020Enhanced cadmium removal from water by hydroxyapatite subjected to different thermal treatmentscitations
- 2017Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopeciacitations
- 2017Enhanced local piezoelectric response in the erbium-doped ZnO nanostructures prepared by wet chemical synthesiscitations
- 2017Nanocrystalline ZnO–SnO<inf>2</inf> mixed metal oxide powder: microstructural study, optical properties, and photocatalytic activitycitations
- 2017Optical and magnetic properties of ZnO/ZnFe<inf>2</inf>O<inf>4</inf>nanocompositecitations
- 2016Erratum: Corrigendum to ‘Ba-doped ZnO nanostructure: X-ray line analysis and optical properties in visible and low frequency infrared’ (Ceramics International (2016) 42 (12860–12867)(10.1016/j.ceramint.2016.05.051)(S0272884216306587))
- 2016Ba-doped ZnO nanostructure: X-ray line analysis and optical properties in visible and low frequency infraredcitations
- 2014Quantum cutting effect and photoluminescence emission at about 1,000 nm from Er–Yb co-doped ZnO nanoplates prepared by wet chemical precipitation methodcitations
- 2014Enhancement of near infrared emission in la co-doped ZnO/Er nanoplatescitations
- 2014Fabricating and characterising ZnO-ZnS-Ag<inf>2</inf>S ternary nanostructures with efficient solar-light photocatalytic activitycitations
- 2014Influence of Mg doping on dielectric and optical properties of ZnO nano-plates prepared by wet chemical methodcitations
- 2014Enhancement of 1536 nm emission of Er doped ZnO nanopowder by Ag dopingcitations
- 2014Far-infrared optical constants of ZnO and ZnO/Ag nanostructurescitations
- 2013A simple recipe for direct writing complex 45S5 Bioglass® 3D scaffoldscitations
- 2013Er doped ZnO nanoplates: Synthesis, optical and dielectric propertiescitations
- 2007Synthesis and mechanical behaviour of chlorapatite and chlorapatite/β-TCP compositescitations
- 2006Novel synthesis and structural characterization of fluorine and chlorine co-substituted hydroxyapatitescitations
Places of action
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article
Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia
Abstract
Background/Aims: Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women. Oral finasteride (FNS), a synthetic 4-aza-3-oxosteroid compound with poor aqueous solubility, blocks the peripheral conversion of testosterone to dihydrotestosterone (DHT) in a significant reduction in DHT concentration, achieving satisfactory results in alopecia treatment. However, its oral intake generally causes severe side effects. Considering that there is currently no scientifically proven treatment, new drug delivery systems able to improve alopecia therapy are urgently required. Methods: In this study, polymeric nanoparticles have been proposed as a new carrier for topical delivery of FNS in hair follicles. Results and Conclusions: Polymeric nanoparticles, prepared by using a modified method of the emulsification/solvent diffusion, showed a mean particle size around 300 nm, which may be sufficient for reaching the dermis and hair follicles and negative zeta potential values. Scanning electron microscope measurements showed that all the polymeric nanoparticles exhibited a spherical shape and a smooth surface regardless of their composition. A high encapsulation efficiency was achieved for FNS (79.49 ± 0.47%). In vitro release assays in physiological conditions demonstrated that nanoparticles yielded a prolonged release of FNS for 3 h. Skin assays through an in vitro permeation study demonstrated that nanoparticles had low levels of penetration of FNS, improving its time residence onto the skin. All excipients used in nanoparticle composition and in 3 different vehicles were safe. These results suggest that the proposed novel formulation presents several good characteristics indicating its suitability for dermal delivery of FNS for alopecia treatment. © 2017 S. Karger AG, Basel.