| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Glišić, Biljana
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (5/5 displayed)
- 2024Copper(II) and Zinc(II) Complexes with Bacterial Prodigiosin Are Targeting Site III of Bovine Serum Albumin and Acting as DNA Minor Groove Binderscitations
- 2024Copper(II) and Zinc(II) Complexes with Bacterial Prodigiosin Are Targeting Site III of Bovine Serum Albumin and Acting as DNA Minor Groove Binderscitations
- 2020Synthesis and spectroscopic characterization of new solid solution containing Mg(II) and Cu(II) complexes with hexadentate 1,3-propanediaminen, N,N’,N’-tetraacetate (1,3-pdta) ligand: In vitro antifungal activity of 1,3-pdta-Cu(II) complexes
- 2019Synthesis and structural analysis of polynuclear silver(I) complexes with 4,7-phenanthrolinecitations
- 2018Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexescitations
Places of action
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article
Hydrolysis of Methionine- and Histidine-Containing Peptides Promoted by Dinuclear Platinum(II) Complexes with Benzodiazines as Bridging Ligands: Influence of Ligand Structure on the Catalytic Ability of Platinum(II) Complexes
Abstract
<jats:p>Dinuclear platinum(II) complexes, [{Pt(en)Cl}<jats:sub>2</jats:sub>(<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mi>μ</mml:mi></mml:math>-qx)]Cl<jats:sub>2</jats:sub>·2H<jats:sub>2</jats:sub>O (<jats:bold>1</jats:bold>), [{Pt(en)Cl}<jats:sub>2</jats:sub>(<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mi>μ</mml:mi></mml:math>-qz)](ClO<jats:sub>4</jats:sub>)<jats:sub>2</jats:sub>(<jats:bold>2</jats:bold>), and [{Pt(en)Cl}<jats:sub>2</jats:sub>(<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mi>μ</mml:mi></mml:math>-phtz)]Cl<jats:sub>2</jats:sub>·4H<jats:sub>2</jats:sub>O (<jats:bold>3</jats:bold>), were synthesized and characterized by different spectroscopic techniques. The crystal structure of<jats:bold>1</jats:bold>was determined by single-crystal X-ray diffraction analysis, while the DFT M06-2X method was applied in order to optimize the structures of<jats:bold>1–3</jats:bold>. The chlorido Pt(II) complexes<jats:bold>1–3</jats:bold>were converted into the corresponding aqua species<jats:bold>1a–3a</jats:bold>, and their reactions with an equimolar amount of Ac–L–Met–Gly and Ac–L–His–Gly dipeptides were studied by<jats:sup>1</jats:sup>H NMR spectroscopy in the pH range 2.0 < pH < 2.5 at 37°C. It was found that, in all investigated reactions with the Ac–L–Met–Gly dipeptide, the cleavage of the Met–Gly amide bond had occurred, but complexes<jats:bold>2a</jats:bold>and<jats:bold>3a</jats:bold>showed lower catalytic activity than<jats:bold>1a</jats:bold>. However, in the reactions with Ac–L–His–Gly dipeptide, the hydrolysis of the amide bond involving the carboxylic group of histidine was observed only with complex<jats:bold>1a</jats:bold>. The observed disparity in the catalytic activity of these complexes is thought to be due to different relative positioning of nitrogen atoms in the bridging qx, qz, and phtz ligands and consequent variation in the intramolecular separation of the two platinum(II) metal centers.</jats:p>