| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Blunn, Gw
University of Portsmouth
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (21/21 displayed)
- 2023Accelerated Degradation of Poly-ε-caprolactone Composite Scaffolds for Large Bone Defectscitations
- 2022Design and in vivo testing of novel single-stage tendon graft using polyurethane nanocomposite polymer for tendon reconstructioncitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implantscitations
- 2018Novel adaptive finite element algorithms to predict bone ingrowth in additive manufactured porous implants.
- 2017Clinical cold welding of the modular total hip arthroplasty prosthesiscitations
- 2017Intrinsic osteoinductivity of porous titanium scaffold for bone tissue engineeringcitations
- 2017Fretting corrosion behavior of nitinol spinal rods in conjunction with titanium pedicle screwscitations
- 2016Corrosion at the head-neck interface of current designs of modular femoral componentscitations
- 2016Metal concentrations in the blood and tissues after implantation of titanium growth guidance sliding instrumentationcitations
- 2016Nanohydroxyapatite effect on the degradation, osteoconduction and mechanical properties of polymeric bone tissue engineered scaffoldscitations
- 2015The effect of frictional torque and bending moment on corrosion at the taper interfacecitations
- 2015Lessons from retrievalscitations
- 2015Analysis of retrieved growth guidance sliding LSZ-4D devices for early onset scoliosis and investigation of the use of nitinol rods for this systemcitations
- 2015Silicate-substituted calcium phosphate with enhanced strut porosity stimulates osteogenic differentiation of human mesenchymal stem cellscitations
- 2014Low dose of propranolol does not affect rat osteotomy healing and callus strengthcitations
- 2013Enhanced wear and corrosion in modular tapers in total hip replacement is associated with the contact area and surface topographycitations
- 2011Enhancing the soft tissue seal around intraosseous transcutaneous amputation prostheses using silanized fibronectin titanium alloycitations
- 2008Composite ceramic bone graft substitute in the treatment of locally aggressive benign bone tumours.citations
- 2006Porous Ti-6Al-4V bone replacement materials produced by Selective Laser Sintering (SLS)
- 2004The effect of diamond like carbon and hydroxyapatite coatings on soft tissue reactions to external fixation screws under load
- 2000Fractographic examination of racing greyhound central (navicular) tarsal bone failure surfaces using scanning electron microscopy
Places of action
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article
Intrinsic osteoinductivity of porous titanium scaffold for bone tissue engineering
Abstract
Large bone defects and nonunions are serious complications that are caused by extensive trauma or tumour. As traditional therapies fail to repair these critical-sized defects, tissue engineering scaffolds can be used to regenerate the damaged tissue. Highly porous titanium scaffolds, produced by selective laser sintering with mechanical properties in range of trabecular bone (compressive strength 35 MPa and modulus 73 MPa), can be used in these orthopaedic applications, if a stable mechanical fixation is provided. Hydroxyapatite coatings are generally considered essential and/or beneficial for bone formation; however, debonding of the coatings is one of the main concerns. We hypothesised that the titanium scaffolds have an intrinsic potential to induce bone formation without the need for a hydroxyapatite coating. In this paper, titanium scaffolds coated with hydroxyapatite using electrochemical method were fabricated and osteoinductivity of coated and noncoated scaffolds was compared in vitro. Alizarin Red quantification confirmed osteogenesis independent of coating. Bone formation and ingrowth into the titanium scaffolds were evaluated in sheep stifle joints. The examinations after 3 months revealed 70% bone ingrowth into the scaffold confirming its osteoinductive capacity. It is shown that the developed titanium scaffold has an intrinsic capacity for bone formation and is a suitable scaffold for bone tissue engineering.