• Lodi, Karina Bortolin
• Santo, Ana Maria Do Espírito
• Marchini, Leonardo
• Rode, Sigmar De Mello
• Rocha, Rosilene Fernandes Da
• Marchini, Adriana Mathias Pereira Da Silva

Abstract

Made available in DSpace on 2019-01-21T10:30:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2016. Added 1 bitstream(s) on 2019-01-21T13:30:34Z : No. of bitstreams: 1 WOS000373141900001.pdf: 1433046 bytes, checksum: 0d766fb79e07f0595935dfc8d8206ef4 (MD5) National Council for Scientific and Technological Development (CNPq-Brazil) Brazilian governmental research agency, National Council for Scientific and Technological Development (CNPq-Brazil) Deficiency of sex hormones and excessive alcohol consumption are factors that have been related to alterations in the pattern of bone mineralization and osteoporosis. The aim of this study was to evaluate possible alterations in the calcium/phosphorus (Ca/P) ratio in the femur of rats subjected to sex hormone deficiency and/or alcohol consumption. Methods. Female andmaleWistar rats (n = 108) were divided into ovariectomized (Ovx), orchiectomized (Orx), or sham-operated groups and subdivided according to diet: alcoholic diet (20% alcohol solution), isocaloric diet, and ad libitum diet. The diets were administered for 8 weeks. The Ca/P ratio in the femur was analyzed by energy dispersive micro-X-ray spectrometer (mu EDX). Results. Consumption of alcohol reduced the Ca/P ratio in both females and males. The isocaloric diet reduced the Ca/P ratio in females. In groups with the ad libitum diet, the deficiency of sex hormones did not change the Ca/P ratio in females or males. However, the combination of sex hormone deficiency and alcoholic diet presented the lowest values for the Ca/P ratio in both females and males. Conclusions. There was a reduced Ca/P ratio in the femur of rats that consumed alcohol, which was exacerbated when combined with a deficiency of sex hormones. Institute of Science and Technology, Department of Biosciences and Diagnostics, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, Brazil Institute of Environmental Science, Chemical and Pharmaceutical, Department of Mathematical and Earth Sciences, Federal University of São Paulo (UNIFESP), Rua Prof. Artur Riedel 275, 09972-270 Diadema, SP, Brazil Institute of Research and Development, University of Vale do Paraíba (UNIVAP), Laboratory of Biomedical Vibrational Spectroscopy, Avenida Shishima Hifumi 2911, 12244-000 São José dos Campos, SP, Brazil Institute of Science and Technology, Department of Dental Materials and Prosthesis, Universidade Estadual Paulista (UNESP), Avenida Engenheiro Francisco José Longo 777, 12245-000 São José dos Campos, SP, Brazil Department of Preventive and Community Dentistry, The University of Iowa College of Dentistry and Dental Clinics, N337-1 Dental Science N, 52242 Iowa City, IA, USA Institute of Environmental Science, Chemical and Pharmaceutical, Department of Mathematical and Earth Sciences, Federal University of São Paulo (UNIFESP), Rua Prof. Artur Riedel 275, 09972-270 Diadema, SP, Brazil Web of Science

Topics

• Energy-dispersive X-ray spectroscopy
• Calcium
• alcohol
• Phosphorus
• vibrational spectroscopy