| People | Locations | Statistics |
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| Naji, M. |
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| Motta, Antonella |
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| Aletan, Dirar |
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| Mohamed, Tarek |
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| Ertürk, Emre |
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| Taccardi, Nicola |
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| Kononenko, Denys |
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| Petrov, R. H. | Madrid |
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| Alshaaer, Mazen | Brussels |
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| Bih, L. |
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| Casati, R. |
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| Muller, Hermance |
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| Kočí, Jan | Prague |
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| Šuljagić, Marija |
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| Kalteremidou, Kalliopi-Artemi | Brussels |
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| Azam, Siraj |
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| Ospanova, Alyiya |
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| Blanpain, Bart |
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| Ali, M. A. |
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| Popa, V. |
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| Rančić, M. |
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| Ollier, Nadège |
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| Azevedo, Nuno Monteiro |
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| Landes, Michael |
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| Rignanese, Gian-Marco |
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Christopher, Rita
in Cooperation with on an Cooperation-Score of 37%
Topics
Publications (6/6 displayed)
- 2014Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Small Vessel Cerebral Stroke in Indian Populationcitations
- 2014Protein Z G79A polymorphism and puerperal cerebral venous thrombosis.citations
- 2012Janus kinase (JAK) 2 V617F mutation in Asian Indians with cerebral venous thrombosis and without overt myeloproliferative disorders.citations
- 2009Association of endothelial nitric oxide synthase gene polymorphisms with early-onset ischemic stroke in South Indians.citations
- 2006Factor V gene A4070G mutation and the risk of cerebral veno-sinus thrombosis occurring during puerperium.citations
- 2006Thrombophilic gene polymorphisms in puerperal cerebral veno-sinus thrombosis.citations
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article
Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism and Small Vessel Cerebral Stroke in Indian Population
Abstract
<jats:p><jats:italic>Background</jats:italic>. Hypertension is an established risk factor for small-vessel cerebral stroke and the renin-angiotensin system plays an important role in the maintenance of blood pressure. We aimed at evaluating the contribution of the angiotensin-converting enzyme (<jats:italic>ACE</jats:italic>) gene insertion/deletion (I/D) polymorphism to the risk of small-vessel stroke in south Indian population.<jats:italic>Materials and Methods</jats:italic>. We investigated 128 patients diagnosed with small-vessel stroke and 236 age, and gender-matched healthy controls.<jats:italic>ACE</jats:italic>I/D polymorphism was detected by polymerase chain reaction.<jats:italic>Results</jats:italic>. Hypertension was significantly more prevalent in the patient group and was associated with 6-fold increase in risk for stroke.<jats:italic>ACE</jats:italic>genotypes were in Hardy-Weinberg equilibrium in both patients and controls. Prevalence of DD, ID, and II genotypes in cases (34.4%, 43.7%, and 28%) did not differ significantly from controls (31.8%, 43.2%, and 25%). The polymorphism was not associated with small-vessel stroke (OR: 1.34; 95% CI: 0.52–1.55). However, diastolic blood pressure was associated with the<jats:italic>ACE</jats:italic>I/D genotypes in the patients. (DD;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:mn>90.2</mml:mn><mml:mo>±</mml:mo><mml:mn>14.2</mml:mn><mml:mo>></mml:mo></mml:mrow></mml:math>ID;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:mn>86.2</mml:mn><mml:mo>±</mml:mo><mml:mn>11.9</mml:mn><mml:mo>></mml:mo></mml:mrow></mml:math>II;<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:mn>82.3</mml:mn><mml:mo>±</mml:mo><mml:mn>7.8</mml:mn></mml:mrow></mml:math> mm Hg,<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mi> </mml:mi><mml:mi> </mml:mi><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.047</mml:mn><mml:mo stretchy="false">)</mml:mo></mml:math>.<jats:italic>Conclusion</jats:italic>. Our study showed that hypertension, but not<jats:italic>ACE</jats:italic>I/D polymorphism, increased the risk of small-vessel stroke.</jats:p>