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Batra, Navneet
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article
No Association of<i>PTGDR</i><i>−441C/T</i>Polymorphism with Asthma in a North Indian Population
Abstract
<jats:p><jats:italic>Background:</jats:italic>Asthma is the most prevalent disease in India according to the national survey conducted by NFHS 2 in 1998–399. Prostaglandin D2 (<jats:italic>PGD2</jats:italic>) is a bronchoconstriction inducing metabolite of arachidonic acid in the mast cells, which is produced on exposure to allergens and acts as a ligand for the Prostaglandin D2 Receptor (<jats:italic>PTGDR</jats:italic>). Polymorphisms in the<jats:italic>PTGDR</jats:italic>gene have been suggested to be involved in the mechanism of asthma.</jats:p><jats:p><jats:italic>Objective:</jats:italic>This is the first study conducted in India, investigating the role of<jats:italic>PTGDR</jats:italic><jats:italic>−441C/T</jats:italic>promoter polymorphism in asthma pathogenesis.</jats:p><jats:p><jats:italic>Methods:</jats:italic>A case-control study was performed with a total of 992 subjects, including 410 adult asthmatics and 582 healthy controls from regions of North India. The<jats:italic>PTGDR</jats:italic><jats:italic>−441C/T</jats:italic>polymorphism was genotyped by Tetra-Primer Amplification Refractory Mutation System Polymerase Chain Reaction (Tetra-Primer ARMS PCR).</jats:p><jats:p><jats:italic>Results:</jats:italic>Statistical analysis of the results between asthma cases and controls for the<jats:italic>PTGDR</jats:italic><jats:italic>−441C/T</jats:italic>polymorphism showed Chi<jats:sup>2</jats:sup>(χ<jats:sup>2</jats:sup>) = 0.29, OR = 0.95, 95% CI (0.70–1.15) and<jats:italic>p</jats:italic>= 0.599. Neither the genotypic nor the allelic frequencies observed for the<jats:italic>PTGDR</jats:italic><jats:italic>−441C/T</jats:italic>polymorphism, were significantly associated with asthma or asthma phenotypes.</jats:p><jats:p><jats:italic>Conclusions:</jats:italic>The<jats:italic>PTGDR</jats:italic><jats:italic>−441C/T</jats:italic>polymorphism is not associated with asthma or its phenotypes in the studied North Indian population.</jats:p>